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AB322794

Biotin Anti-PICP antibody [EPR22209-103] (Detector)

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Rabbit Recombinant Monoclonal COL1A1 antibody - conjugated to Biotin. Suitable for sELISA and reacts with Human samples.

View Alternative Names

Collagen alpha-1(I) chain, Alpha-1 type I collagen, COL1A1

  • Carrier free

    Anti-PICP antibody [EPR22209-103] - BSA and Azide free (Detector)

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR22209-103

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Product details

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PICP also known as procollagen type 1 C-peptide or collagen C-peptide is a byproduct released during the synthesis of type I collagen. Type I collagen is the most abundant collagen type in the human body providing structure to skin bone tendons and other connective tissues. PICP has a molecular mass of approximately 35-38 kDa. It is expressed in tissues where type I collagen is synthesized including bone and skin fibroblasts.
Biological function summary

PICP serves as a marker for collagen biosynthesis closely reflecting the rate of collagen type I production. PICP does not form part of a larger complex but exists as a separate entity once cleaved from procollagen. Its presence in the bloodstream allows researchers to monitor collagen turnover which is vital in understanding tissue formation and remodeling processes.

Pathways

PICP connects with collagen synthesis and deposition pathways particularly relevant in bone formation and skin repair. It interacts indirectly with proteins like collagenase during collagen degradation and remodeling. Increased PICP levels indicate heightened collagen synthesis correlating with anabolic processes especially in bone metabolism pathways.

PICP levels are significant in bone-related conditions like osteoporosis where decreased collagen synthesis is often observed. It also correlates with fibrotic conditions including liver fibrosis where elevated collagen production marks disease progression. In these contexts PICP relates to other proteins such as procollagen type III N-peptide (PIIINP) which also serve as markers of pathological collagen deposition.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Type I collagen is a member of group I collagen (fibrillar forming collagen).
See full target information COL1A1
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Product promise

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For full details, please see our Terms & Conditions

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