JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB82799

Biotin Anti-PTHLH antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Anti-PTHLH antibody conjugated to Biotin is a rabbit polyclonal antibody suitable for Western blot, sELISA, and reacts with human samples.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

WB, sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PTHLH.

P12272

style
left-column

Alternative Products

Primary Antibodies

AB224503

Anti-PTHLH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTHLH antibody (AB224503)

  • 4
  • 1
Primary Antibodies

AB79539

Anti-PTHLH antibody [3D1.1]

  • 0
  • 0
Primary Antibodies

AB197358

Anti-PTHLH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTHLH antibody (AB197358)

  • 4
  • 1
Primary Antibodies

AB239527

Anti-PTHLH antibody [D1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PTHLH antibody [D1] (AB239527)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB52919

Anti-Ihh antibody [EP1192Y]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ihh antibody [EP1192Y] (AB52919)

  • 2
  • 1
Primary Antibodies

AB254257

Anti-POMC antibody [EPR22534-165]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-POMC antibody [EPR22534-165] (AB254257)

  • 4
  • 1
Primary Antibodies

AB11056

Anti-COMP/Cartilage oligomeric matrix protein antibody [MA37C94 (HC484D1)]

  • 4
  • 2
Primary Antibodies

AB45139

Anti-Vitronectin/S-Protein antibody [EP873Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Vitronectin/S-Protein antibody [EP873Y] (AB45139)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>Can be used as detection antibody when paired with recommended antibody.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in sterile PBS containing 0.1% BSA to give a concentration of 0.1 - 1.0 mg/ml.
Purification technique
Affinity purification Immunogen
Purification notes
ab82799 was purified by affinity chromatography and then biotinylated.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Parathyroid hormone-like hormone (PTHLH) also known as PTHrP is a protein made by the PTHLH gene. It weighs around 17 kDa and its expression occurs in many tissues including the bone skin and developing structures during embryogenesis. PTHLH interacts with parathyroid hormone receptors offering actions similar to parathyroid hormone (PTH). This interaction helps to extend its role beyond classical calcium homeostasis to include other functions such as growth and developmental processes.
Biological function summary

PTHLH plays a role in cartilage development and endochondral bone formation. It functions as a significant regulator of cellular proliferation and differentiation especially in chondrocytes and osteoblasts. PTHLH can also act as part of multiprotein complexes that influence transcription and intracellular signaling. Furthermore it possesses diverse roles including smooth muscle contraction mammary gland development and cellular differentiation inhibition.

Pathways

Alongside related proteins like Indian Hedgehog (IHH) PTHLH resides in pathways critical for skeletal development and homeostasis. Notably the PTHLH/PTHR1 signaling pathway regulates chondrocyte maturation during bone growth. This pathway intersects with the Hedgehog pathway to form a regulatory loop essential for maintaining the growth plate's development and maturation. PTHLH also influences the Wnt signaling pathway associated with bone density and health.

PTHLH has connections with certain cancers specifically breast cancer and hypercalcemia of malignancy. In cancerous tissues PTHLH can be overexpressed leading to increased osteoclastic bone resorption contributing to cancer-associated conditions. Additionally PTHLH overactivity links it to familial benign hypercalcemia through its interactions with PTH and its receptors. Understanding these associations could offer therapeutic targets for treatment.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed : 12538599, PubMed : 35932760, PubMed : 3616618). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed : 19674967, PubMed : 35932760). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (PubMed : 12538599). Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (PubMed : 12538599). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion (By similarity). BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1 (PubMed : 20637541).. Osteostatin. Potent inhibitor of osteoclastic bone resorption.
See full target information PTHLH

Alternative Names

PTHRP, PTHLH, Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Bioelectrochemistry (Amsterdam, Netherlands) 128:165-174 PubMed31004910

2019

Nanostructured Au-Pt hybrid disk electrodes for enhanced parathyroid hormone detection in human serum.

Applications

Unspecified application

Species

Unspecified reactive species

Ajay Kumar Yagati,Anna Go,Sachin Ganpat Chavan,Changyoon Baek,Min-Ho Lee,Junhong Min
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com