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AB39628

Biotin Anti-RELM alpha/Retnla antibody

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(3 Publications)

Rabbit Polyclonal RELM alpha/Retnla antibody - conjugated to Biotin. Suitable for Flow Cyt, WB, sELISA and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Retnla.

View Alternative Names

Fizz1, Himf, Pmng1, Retnla, Resistin-like alpha, Cysteine-rich secreted protein A12-gamma, Cysteine-rich secreted protein FIZZ1, Hypoxia-induced mitogenic factor, Parasite-induced macrophage novel gene 1 protein, RELMalpha

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Mouse

Applications

sELISA, WB, Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Retnla.

Q9EP95

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Alternative Products

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AB39626

Anti-RELM alpha/Retnla antibody

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/biotin-rabbit-igg-isotype-control-ab200208'>ab200208</a> - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.</p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with PBS, 0.1% BSA at 50µg/mL
Purification technique
Affinity purification Immunogen
Purification notes
Purified by affinity chromatography and then biotinylated.
Storage buffer
Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RELM alpha also known as Retnla is a small secreted protein with a molecular mass of approximately 10 kDa. It belongs to the resistin-like molecule family and is mainly expressed in adipose tissues and the lungs. However some expression also occurs in the gastrointestinal tract and immune cells. It plays a role as a signaling molecule and is secreted under various physiological and pathological conditions.
Biological function summary

RELM alpha functions as a modulator of immune responses and inflammation. It has a part in the immune network and participates in the regulation of insulin sensitivity. While it does not form part of a specific complex it interacts with other cytokines and chemokines to modulate the activity of macrophages and other immune cells. This modulation impacts the balance between pro-inflammatory and anti-inflammatory signals in the body.

Pathways

RELM alpha plays roles in the metabolic and immune pathways. It influences the toll-like receptor signaling pathway which involves key proteins like TLR4 which is essential for pathogen recognition and innate immunity. RELM alpha also appears in pathways related to glucose metabolism interacting with other metabolic regulators to affect energy homeostasis and insulin action.

RELM alpha has connections to conditions like obesity and asthma. In obesity levels of RELM alpha may correlate with inflammatory states and insulin resistance interacting with proteins like adiponectin and leptin. In asthma RELM alpha may contribute to airway inflammation working alongside proteins like IL-13 to drive inflammatory responses in the respiratory system. These associations make RELM alpha a significant target for therapeutic investigation in related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probable hormone. Plays a role in pulmonary vascular remodeling.
See full target information Retnla
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:39714 PubMed28004808

2016

IL-13 is a therapeutic target in radiation lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Su I Chung,Jason A Horton,Thirumalai R Ramalingam,Ayla O White,Eun Joo Chung,Kathryn E Hudak,Bradley T Scroggins,Joseph R Arron,Thomas A Wynn,Deborah E Citrin

Nature communications 7:13130 PubMed27731330

2016

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.

Applications

WB

Species

Unspecified reactive species

Tetsuya Kimura,Shigeyuki Nada,Noriko Takegahara,Tatsusada Okuno,Satoshi Nojima,Sujin Kang,Daisuke Ito,Keiko Morimoto,Takashi Hosokawa,Yoshitomo Hayama,Yuichi Mitsui,Natsuki Sakurai,Hana Sarashina-Kida,Masayuki Nishide,Yohei Maeda,Hyota Takamatsu,Daisuke Okuzaki,Masaki Yamada,Masato Okada,Atsushi Kumanogoh

The Journal of experimental medicine 208:1863-74 PubMed21825018

2011

Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway.

Applications

Flow Cyt

Species

Mouse

Julius A Potian,Wasiulla Rafi,Kamlesh Bhatt,Amanda McBride,William C Gause,Padmini Salgame
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Product promise

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