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AB252755

Biotin Anti-Rotavirus NCDV antibody

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Goat Polyclonal Rotavirus NCDV antibody - conjugated to Biotin. Suitable for Fluorescence Microscopy and reacts with Rotavirus samples. Immunogen corresponding to Virus preparation containing Rotavirus NCDV protein.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Rotavirus

Applications

Fluorescence Microscopy

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Complementary Products

Primary Antibodies

AB181695

Anti-Rotavirus antibody [A2]

  • 5
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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Assay Kits

AB252889

Acid Sphingomyelinase Assay Kit (Colorimetric)

Enzyme activity assay - Acid Sphingomyelinase Assay Kit (Colorimetric) (AB252889)

  • 0
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Secondary Antibodies

AB112817

Goat Anti-Chicken IgA H&L (HRP)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FluorescenceMicroscopy" : {"fullname" : "Fluorescence Microscopy", "shortname":"Fluorescence Microscopy"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rotavirus": { "FluorescenceMicroscopy-species-checked": "guaranteed", "FluorescenceMicroscopy-species-dilution-info": "", "FluorescenceMicroscopy-species-notes": "<p>Suitable for use with avidin and streptavidin amplification systems for fluorescence microscopy. Each laboratory should determine an optimum working titer for use in its particular application.</p>" } } }
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Purification notes
IgG fraction covalently coupled with the N-Hydroxysuccinimide ester of Biotin under mild conditions to give a high degree of substitution.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Rotavirus NCDV also known as the Neonatal Calf Diarrhea Virus is an RNA virus that causes diarrhea in young animals. Its structure includes a capsid protein complex with a molecular mass of approximately 88 kDa. The virus is expressed specifically in the intestines where it infects the epithelial cells. Rotavirus NCDV has several structural proteins including VP4 VP6 and VP7. These proteins play a major role in the virus's ability to infect host cells and cause disease.
Biological function summary

Rotavirus NCDV initiates infection by attaching to cellular receptors on the intestinal epithelium. It is a part of a complex that allows entry into cells leading to the replication of viral RNA. The viral replication inside the host cells disrupts normal cellular function resulting in loss of water and electrolytes and ultimately in diarrhea. The virus elicits an immune response but the rapid replication can overwhelm the host defenses leading to the symptoms observed in infected individuals.

Pathways

Rotavirus NCDV primarily impacts the gastrointestinal signaling pathways. It interacts with proteins such as integrins which are involved in cell adhesion and communication in the intestinal lining. The NSP4 protein of rotavirus acts as an enterotoxin and regulates calcium ion signaling pathways further contributing to the diarrheal effect. These interactions interfere with the cellular homeostasis and can lead to villus atrophy.

Rotavirus NCDV is associated primarily with acute infantile diarrhea and diarrhea in young livestock. It is closely connected to NSP4-related pathologies due to its role as a viral enterotoxin. This protein's mechanism of promoting calcium release contributes to fluid secretion in the intestines. NSP4 and other rotavirus proteins such as VP4 are targets for vaccine development to prevent rotavirus-induced diarrheal diseases indicating their importance in controlling outbreaks.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Rotavirus NCDV
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Product promise

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