Goat Polyclonal Rotavirus NCDV antibody - conjugated to Biotin. Suitable for Fluorescence Microscopy and reacts with Rotavirus samples. Immunogen corresponding to Virus preparation containing Rotavirus NCDV protein.
Preservative: 0.1% Sodium azide
Constituents: PBS
| Fluorescence Microscopy | |
|---|---|
| Rotavirus | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Rotavirus | Dilution info - | Notes Suitable for use with avidin and streptavidin amplification systems for fluorescence microscopy. Each laboratory should determine an optimum working titer for use in its particular application. |
Nebraska calf diarrhea virus, Rotavirus
Goat Polyclonal Rotavirus NCDV antibody - conjugated to Biotin. Suitable for Fluorescence Microscopy and reacts with Rotavirus samples. Immunogen corresponding to Virus preparation containing Rotavirus NCDV protein.
Preservative: 0.1% Sodium azide
Constituents: PBS
IgG fraction covalently coupled with the N-Hydroxysuccinimide ester of Biotin under mild conditions to give a high degree of substitution.
Rotavirus NCDV also known as the Neonatal Calf Diarrhea Virus is an RNA virus that causes diarrhea in young animals. Its structure includes a capsid protein complex with a molecular mass of approximately 88 kDa. The virus is expressed specifically in the intestines where it infects the epithelial cells. Rotavirus NCDV has several structural proteins including VP4 VP6 and VP7. These proteins play a major role in the virus's ability to infect host cells and cause disease.
Rotavirus NCDV initiates infection by attaching to cellular receptors on the intestinal epithelium. It is a part of a complex that allows entry into cells leading to the replication of viral RNA. The viral replication inside the host cells disrupts normal cellular function resulting in loss of water and electrolytes and ultimately in diarrhea. The virus elicits an immune response but the rapid replication can overwhelm the host defenses leading to the symptoms observed in infected individuals.
Rotavirus NCDV primarily impacts the gastrointestinal signaling pathways. It interacts with proteins such as integrins which are involved in cell adhesion and communication in the intestinal lining. The NSP4 protein of rotavirus acts as an enterotoxin and regulates calcium ion signaling pathways further contributing to the diarrheal effect. These interactions interfere with the cellular homeostasis and can lead to villus atrophy.
Rotavirus NCDV is associated primarily with acute infantile diarrhea and diarrhea in young livestock. It is closely connected to NSP4-related pathologies due to its role as a viral enterotoxin. This protein's mechanism of promoting calcium release contributes to fluid secretion in the intestines. NSP4 and other rotavirus proteins such as VP4 are targets for vaccine development to prevent rotavirus-induced diarrheal diseases indicating their importance in controlling outbreaks.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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