Goat Polyclonal SCGF antibody - conjugated to Biotin. Suitable for sELISA, WB and reacts with Recombinant fragment - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLEC11A.
Constituents: PBS, 0.1% BSA
| sELISA | WB | |
|---|---|---|
| Human | Predicted | Predicted |
| Recombinant fragment - Human | Tested | Tested |
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment - Human | Dilution info 0.25-1 µg/mL | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment - Human | Dilution info 0.1-0.2 µg/mL | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
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Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999). Important for repair and maintenance of adult bone (By similarity).
CLECSF3, LSLCL, SCGF, CLEC11A, C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Osteolectin, Stem cell growth factor, p47
Goat Polyclonal SCGF antibody - conjugated to Biotin. Suitable for sELISA, WB and reacts with Recombinant fragment - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLEC11A.
Constituents: PBS, 0.1% BSA
SCGF beta also known as stem cell growth factor beta or CLEC11A is a cytokine with a mass of approximately 32 kDa. It is expressed in various tissues including bone marrow spleen and liver. SCGF beta plays a role in hematopoiesis influencing the growth and differentiation of stem cells. The protein interacts with surface receptors on target cells leading to intracellular signaling cascades that drive its functions.
SCGF beta promotes the proliferation and differentiation of hematopoietic progenitor cells. It serves as a mediator in the bone marrow microenvironment supporting the survival and maintenance of stem cells. While it functions independently SCGF beta may interact with other cytokines to optimize the hematopoietic process. Its activity is not known to rely on a larger protein complex.
SCGF beta is integral to the hematopoietic and immune response pathways. It contributes significantly to erythropoiesis and granulopoiesis key components of blood cell formation. In these pathways SCGF beta relates closely to proteins like G-CSF and GM-CSF which also stimulate granulocyte and macrophage lineage differentiation. Together these proteins ensure the proper development and function of blood cells and the immune system.
SCGF beta has associations with conditions such as leukemia and bone marrow failure syndromes. Altered expression or malfunction of SCGF beta may contribute to the pathogenesis of these disorders by disrupting normal hematopoietic processes. In leukemia a relationship exists between SCGF beta and proteins like FLT3 where mutations can exacerbate the condition by affecting cell signaling and growth. Understanding SCGF beta's role in these diseases may provide insight into better therapeutic strategies.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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