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AB84442

Biotin Anti-SCGF beta antibody

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(1 Publication)

Goat Polyclonal SCGF antibody - conjugated to Biotin. Suitable for sELISA, WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLEC11A.

View Alternative Names

CLECSF3, LSLCL, SCGF, CLEC11A, C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Osteolectin, Stem cell growth factor, p47

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

WB, sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CLEC11A.

Q9Y240

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "0.25-1 µg/mL", "sELISA-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with PBS, 0.1% BSA at 50µL
Purification technique
Affinity purification Immunogen
Storage buffer
Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCGF beta also known as stem cell growth factor beta or CLEC11A is a cytokine with a mass of approximately 32 kDa. It is expressed in various tissues including bone marrow spleen and liver. SCGF beta plays a role in hematopoiesis influencing the growth and differentiation of stem cells. The protein interacts with surface receptors on target cells leading to intracellular signaling cascades that drive its functions.
Biological function summary

SCGF beta promotes the proliferation and differentiation of hematopoietic progenitor cells. It serves as a mediator in the bone marrow microenvironment supporting the survival and maintenance of stem cells. While it functions independently SCGF beta may interact with other cytokines to optimize the hematopoietic process. Its activity is not known to rely on a larger protein complex.

Pathways

SCGF beta is integral to the hematopoietic and immune response pathways. It contributes significantly to erythropoiesis and granulopoiesis key components of blood cell formation. In these pathways SCGF beta relates closely to proteins like G-CSF and GM-CSF which also stimulate granulocyte and macrophage lineage differentiation. Together these proteins ensure the proper development and function of blood cells and the immune system.

SCGF beta has associations with conditions such as leukemia and bone marrow failure syndromes. Altered expression or malfunction of SCGF beta may contribute to the pathogenesis of these disorders by disrupting normal hematopoietic processes. In leukemia a relationship exists between SCGF beta and proteins like FLT3 where mutations can exacerbate the condition by affecting cell signaling and growth. Understanding SCGF beta's role in these diseases may provide insight into better therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed : 27976999). Important for repair and maintenance of adult bone (By similarity).
See full target information CLEC11A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer diagnosis & prognosis 5:1-7 PubMed39758242

2025

High Tumoral KPNA2 Expression Is a PotentialBiomarker for Poor Prognosis in Advanced Neuroblastoma Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Sayaka Otake,Kenjiro Ogushi,Gendensuren Dorjkhorloo,Takehiko Yokobori,Akira Nishi,Hiroyuki Kuwano,Hiroshi Saeki,Ken Shirabe
View all publications
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Product promise

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