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AB35192

Biotin Anti-Staphylococcus aureus antibody

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(3 Publications)

Rabbit Polyclonal Staphylococcus aureus antibody - conjugated to Biotin. Suitable for ICC/IF and reacts with Staphylococcus aureus samples. Cited in 3 publications. Immunogen corresponding to Cell preparation containing Staphylococcus aureus protein.

View Alternative Names

IgG binding protein A, Immunoglobulin G binding protein A

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Staphylococcus aureus

Applications

ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Reacts with soluble and structural antigens of the whole bacterium.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Staphylococcus aureus": { "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Proprietary technique
Purification notes
Purified IgG conjugated to Biotin.
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Staphylococcus aureus also known as "aureus" or "staph" is a gram-positive bacterium with a molecular mass ranging around 2.8 million daltons. It is found mainly in the nasal passages and on the skin of humans. This bacterium has a thick peptidoglycan layer making it resistant to certain environmental pressures. The structure of its proteins like Protein A plays an important role in immune evasion. Staphylococcus aureus also expresses a variety of toxins and enzymes that aid in its survival and pathogenicity.
Biological function summary

Staphylococcus aureus acts as an opportunistic pathogen that can cause infections when the host's immune system is weakened. It is not part of a specific protein complex but utilizes a range of virulence factors to establish infections. The bacterium produces biofilms which provide a protective environment against host defenses and antimicrobial agents. Its ability to quickly adapt to different environments makes it a major cause of both nosocomial and community-acquired infections.

Pathways

The metabolic activities of Staphylococcus aureus are involved in two significant pathways: the peptidoglycan biosynthesis and the toxin production pathway. Peptidoglycan biosynthesis is essential for cell wall integrity while toxin production pathways lead to the synthesis of critical virulence factors like alpha-hemolysin. Key proteins involved in these pathways include PBP2a which is significant for methicillin resistance and hemolysins that damage host tissues.

Staphylococcus aureus is connected to skin infections and pneumonia. The bacterium is notorious for causing conditions such as MRSA (methicillin-resistant Staphylococcus aureus) infections which are challenging to treat due to antibiotic resistance. Protein A interaction with the Fc region of immunoglobulin contributes to the evasion of immune responses and chronic infection persistence. These properties make staph infections a significant concern in both hospital and community settings.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Polymers 12: PubMed32414196

2020

Anti- Functionalized Silver-Doped Carbon Nanofibers for Capture of in Microfluidic Systems.

Applications

Unspecified application

Species

Unspecified reactive species

Soshana Smith,Michael Delaney,Margaret Frey

ACS nano 12:2554-2559 PubMed29522316

2018

Computational Sensing of Staphylococcus aureus on Contact Lenses Using 3D Imaging of Curved Surfaces and Machine Learning.

Applications

Unspecified application

Species

Unspecified reactive species

Muhammed Veli,Aydogan Ozcan

The Journal of infectious diseases 209:1533-41 PubMed24280367

2013

Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Binh An Diep,Qui Phung,Shailesh Date,David Arnott,Corey Bakalarski,Min Xu,Gerald Nakamura,Danielle L Swem,Mary Kate Alexander,Hoan N Le,Thuy T Mai,Man-Wah Tan,Eric J Brown,Mireille Nishiyama
View all publications

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