Rabbit Polyclonal TARC/CCL17 antibody - conjugated to Biotin. Carrier free. Suitable for sELISA, WB and reacts with Recombinant fragment - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCL17.
IgG
Rabbit
Biotin
Constituents: PBS
Lyophilized
Polyclonal
| sELISA | WB | |
|---|---|---|
| Human | Predicted | Predicted |
| Recombinant fragment - Human | Tested | Tested |
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment - Human | Dilution info 0.25-1 µg/mL | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Recombinant fragment - Human | Dilution info 0.1-0.2 µg/mL | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Select an associated product type
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
C-C motif chemokine 17, CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, SCYA17, CCL17, TARC
Rabbit Polyclonal TARC/CCL17 antibody - conjugated to Biotin. Carrier free. Suitable for sELISA, WB and reacts with Recombinant fragment - Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCL17.
C-C motif chemokine 17, CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, SCYA17, CCL17, TARC
IgG
Rabbit
Biotin
Constituents: PBS
Lyophilized
Polyclonal
Yes
Centrifuge vial prior to opening. Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
ab84279 was purified by affinity chromatography and then biotinylated.It is sterile filtered.
Blue Ice
1-2 weeks
+4°C
-20°C
Avoid freeze / thaw cycle
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TARC also known as CCL17 is a chemokine with a molecular mass of approximately 8 kDa. It is mainly expressed in the thymus but also found in the lung liver and lymph nodes. CCL17 plays an important role in immune response by signaling through the CCR4 receptor. It functions as a ligand that guides the movement of T-helper 2 (Th2) cells regulatory T cells (Tregs) and other immune cells to sites of inflammation.
CCL17 acts as a chemotactic agent attracting specific immune cells especially T lymphocytes to inflammatory regions. This protein does not operate as part of a larger protein complex but engages directly by binding to receptors on the target immune cells. Localized expression of CCL17 increases in conditions where enhanced Th2 cell response is needed such as allergic or autoimmune responses.
CCL17 plays a significant role in the cell signaling pathway called the chemokine signaling pathway. Through this pathway CCL17 interacts with the CCR4 receptor which helps mediate immune cell migration and adhesion. This interaction is critical for establishing the adaptive immune response. CCL17 and CCR4 support the trafficking of Th2 cells during immune reactions and pathogen defense.
CCL17 associates with asthma and atopic dermatitis where Th2 cell recruitment and activity are heightened. In asthma increased CCL17 levels exacerbate inflammatory response in the airways. In atopic dermatitis CCL17 presence corresponds with the intensity of the skin inflammation. These conditions are linked to the overactivity of Th2 cytokines such as IL-4 (H4L3) which collaborate with CCL17 to drive allergic responses.
We have tested this species and application combination and it works. It is covered by our product promise.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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