Biotin Anti-Toxoplasma gondii antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Toxoplasma gondii manipulates the host’s immune response to survive and multiply. Within the host it exists as a complex of organelles called the apicoplast which is important for lipid synthesis and metabolism. The parasite modifies the host cells to create a protective environment by blocking host immune signaling pathways. It also affects host’s cell apoptosis promoting the persistence of infection.

Pathways

Toxoplasma gondii integrates itself within both immune and metabolic pathways in the host. The parasite affects the NF-kB signaling pathway which influences host immune response allowing it to evade detection. It also interacts with host cell’s cytokines like interleukin-12 (IL-12) and interferon-gamma (IFN-γ) which are proteins important for immune system modulation and control.