Biotin Anti-Uteroglobin antibody [EPR19846]
- BOND RX™ Validated
- Recombinant
- RabMAb
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Rabbit Recombinant Monoclonal Uteroglobin antibody - conjugated to Biotin. Suitable for IHC-P and reacts with Mouse samples.
View Alternative Names
Cc10, Ugb, Utg, Scgb1a1, Uteroglobin, Club cell 17 kDa protein, Club cell phospholipid-binding protein, Club cells 10 kDa secretory protein, PCB-binding protein, Secretoglobin family 1A member 1, CCPBP, CC10
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Uteroglobin antibody [EPR19846] (AB321781)](https://content.abcam.com/products/images/biotin-uteroglobin-antibody-epr19846-ab321781--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img435799.jpg/_jcr_content/renditions/webp-768.webp)
- IHC-P
Lab
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Uteroglobin antibody [EPR19846] (AB321781)
Negative staining of Uteroglobin in a section of formalin-fixed paraffin-embedded mouse normal cerebral cortex.
Performed on a Leica BOND™ system. The section was pre-treated using heat mediated antigen retrieval with EDTA buffer (pH 9.0, epitope retrieval solution 2) for 20mins, before blocking of endogenous biotin using ab64212. The section was then incubated with ab321781 at 0.1 μg/ml (1/5000), for 15 mins at room temperature and detected using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset secondary-only control image is taken from an identical assay without primary antibody.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Uteroglobin antibody [EPR19846] (AB321781)](https://content.abcam.com/products/images/biotin-uteroglobin-antibody-epr19846-ab321781--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img435798.jpg/_jcr_content/renditions/webp-768.webp)
- IHC-P
Lab
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Uteroglobin antibody [EPR19846] (AB321781)
IHC image of Uteroglobin staining in a section of formalin-fixed paraffin-embedded mouse lung.
Performed on a Leica BOND™ system. The section was pre-treated using heat mediated antigen retrieval with EDTA buffer (pH 9.0, epitope retrieval solution 2) for 20mins, before blocking of endogenous biotin using ab64212. The section was then incubated with ab321781 at 0.1 μg/ml (1/5000), for 15 mins at room temperature and detected using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset secondary-only control image is taken from an identical assay without primary antibody.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
Related conjugates and formulations (2)
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Anti-Uteroglobin antibody [EPR19846]
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Anti-Uteroglobin antibody [EPR19846] - BSA and Azide free
Reactivity data
Product details
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties and storage information
Form
Purification technique
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Uteroglobin serves as a multifunctional secretory agent contributing to the regulation of inflammation and tissue remodeling. It does not form part of a larger complex but acts independently. By binding and inhibiting pro-inflammatory mediators like phospholipase A2 Uteroglobin reduces the production of arachidonic acid derivatives which are involved in inflammatory processes. Additionally it acts as a chemoattractant for certain immune cells further modulating immune responses.
Pathways
Uteroglobin integrates into the immune response and inflammation pathways. It indirectly interacts with proteins such as cytokines and chemokines influencing pathways like the arachidonic acid metabolism pathway and the leukocyte extravasation signaling pathway. These interactions reduce inflammatory response and regulate immune cell movement demonstrating its anti-inflammatory function.
Product protocols
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Target data
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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