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AB2521

Anti-Blood Group A Antigen antibody [HE-193]

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(4 Publications)

Mouse Monoclonal ABO antibody. Suitable for Agg, IHC-P and reacts with Human samples. Cited in 4 publications.

View Alternative Names

Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, Histo-blood group B transferase, NAGAT, A transferase, B transferase, ABO

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HE-193

Isotype

IgM

Light chain type

unknown

Carrier free

No

Reacts with

Human

Applications

IHC-P, Agg

applications

Specificity

This antibody recognizes human blood group A (monofucosyl and difucosyl A antigens with chain types 1, 2, 3, 4, 5, 6) and Forssman antigen.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "Agg" : {"fullname" : "Agglutination", "shortname":"Agg"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "Agg-species-checked": "guaranteed", "Agg-species-dilution-info": "", "Agg-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Purification notes
Concentrated by ultrafiltration (100 kDa cut-off). Actual immunoglobulin concentration not determined.
Storage buffer
Constituents: Tissue culture supernatant
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Blood Group A Antigen also known as the A antigen is associated with the ABO blood group system. It is a glycoprotein located on the surface of red blood cells and various other cell types. The A antigen is characterized by its unique carbohydrate moiety which presents a specific sequence of monosaccharides. The A antigen has a molecular mass close to 100 kDa. Expression of the A antigen varies among individuals being found in those with blood type A and AB as well as in certain epithelial tissues and secretions.
Biological function summary

This antigen plays a significant role in human blood typing influencing transfusion compatibility and organ transplantation. It is not part of a larger molecular complex yet it interacts with antibodies specific to blood type. The presence of the A antigen is a factor in the immune response particularly with the generation of anti-B antibodies in individuals with blood type A. This interaction is an integral part of the body's defense mechanisms helping to determine self from non-self.

Pathways

The A antigen is central to the ABO antigen system a major pathway influencing immune reactions. This system involves the action of glycosyltransferase enzymes such as the A transferase which assist in the synthesis of the A antigen. These enzymes share relation with the B transferase in the pathways differing only in substrate specificity. Besides cross-reactions involving these antigens mediate the interactions with certain infectious agents incorporating them into the innate immune response.

The A antigen carries associations with transfusion reactions and hemolytic disease of the newborn. In transfusion reactions incompatibility between donor and recipient blood types results in destruction of red blood cells involving complement proteins. The A antigen also impacts susceptibility to certain infections like H. pylori as its presence can enhance bacterial adherence. Understanding the relationships between antigens and these conditions assists in developing therapies and compatibility matches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens : A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.. Glycosyltransferase that catalyzes the transfer of carbohydrates to H antigen, forming the antigenic structures of the ABO blood group.
See full target information Histo-blood group ABO system transferase
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 22: PubMed34208903

2021

Characterization of Glycosphingolipids in the Human Parathyroid and Thyroid Glands.

Applications

Unspecified application

Species

Unspecified reactive species

Karin Säljö,Anders Thornell,Chunsheng Jin,Peter Stålberg,Olov Norlén,Susann Teneberg

Journal of orthopaedic translation 21:129-135 PubMed32309138

2020

Association between the ABO blood group and primary knee osteoarthritis: A case-control study.

Applications

Unspecified application

Species

Unspecified reactive species

Changchuan Li,Nengtai Ouyang,Xiuju Wang,Anjing Liang,Yingqian Mo,Shixun Li,Junxiong Qiu,Guibin Fang,Yuan Fu,Bin Song,Zhong Chen,Yue Ding

Glycoconjugate journal 32:393-412 PubMed26104834

2015

Characterization of moose intestinal glycosphingolipids.

Applications

Unspecified application

Species

Unspecified reactive species

Miralda Madar Johansson,Benjamin Dedic,Klara Lundholm,Filip Berner Branzell,Angela Barone,John Benktander,Susann Teneberg

Vox sanguinis 52:125-8 PubMed2440181

1987

Murine monoclonal antibodies to human A erythrocytes: differential reactivity with N-acetyl-D-galactosamine.

Applications

Unspecified application

Species

Unspecified reactive species

M Nĕmec,D Drímalová,V Horejsí,J Vanák,J Bártek,V Viklický
View all publications
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