Mouse Monoclonal ABO antibody. Carrier free. Suitable for Agg, IHC-P and reacts with Human samples. Cited in 7 publications.
Constituents: Tissue culture supernatant
| Agg | IHC-P | |
|---|---|---|
| Human | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes The minimum titre is 1:128 with erythrocytes of blood group B. |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
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This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. Glycosyltransferase that catalyzes the transfer of carbohydrates to H antigen, forming the antigenic structures of the ABO blood group.
Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, Histo-blood group B transferase, NAGAT, A transferase, B transferase, ABO
Mouse Monoclonal ABO antibody. Carrier free. Suitable for Agg, IHC-P and reacts with Human samples. Cited in 7 publications.
Constituents: Tissue culture supernatant
This antibody recognizes human blood group B antigens. The specificity of the antibody HEB-29 was confirmed by comparison of specificity and reactivity to standard reagent using >5.000 samples of blood.
Concentrated by ultrafiltration (100 kDa cut-off). Actual immunoglobulin concentration not determined.
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The Blood Group B Antigen commonly called the B antigen is a carbohydrate antigen found on the surface of red blood cells. This antigen is part of the ABO blood group system which determines an individual's blood type. The B antigen's molecular composition consists primarily of a sugar molecule called D-galactose. The B antigen is expressed on the erythrocyte surface and is encoded by the B allele of the ABO gene. Individuals with blood type B will have the B antigen on the surface of their red blood cells and do not have anti-B antibodies in their plasma. The mass of the B antigen can vary depending on the glycoproteins and glycolipids it attaches to on the membrane.
The B antigen's presence on red blood cells plays a fundamental role in immune system recognition and compatibility during blood transfusions. It is not part of a complex but associates directly with the cell membrane structures. The presence of particular carbohydrate sequences such as those of the B antigen allows the immune system to distinguish between self and non-self cells. Known as anti-B antibodies these antibodies exist in individuals who do not express the B antigen specifically those with blood type A or O.
Blood Group B Antigen contributes significantly to the ABO blood group system's immunological pathway. This pathway includes biosynthesis and degradation processes involving the glycosyltransferase enzyme responsible for adding sugar residues to the precursor substance to form specific antigens. Glycosyltransferase is related to protein pathways that handle energy metabolism and cellular processes due to its enzymatic role in forming cell surface markers like the B antigen.
The B antigen is linked to transfusion reactions and hemolytic disease of the newborn (HDN). Incompatibility between donor and recipient blood types during transfusions can cause immunological reactions where anti-B antibodies attack the B antigens. These reactions can lead to severe complications. HDN occurs when a mother with type O blood carries a baby with type B blood resulting in anti-B antibodies attacking fetal red blood cells. This emphasizes the clinical significance of the B antigen in blood type compatibility and transfusion medicine.
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