Anti-BMP2 antibody (ab14933) is a rabbit polyclonal antibody detecting BMP2 in Western Blot. Suitable for Human.
- Over 170 publications
- Trusted since 2004
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- Asian biomedicine : research, reviews and news 16:237-2482023Ameliorative effect of different mesoporous bioactive glass materials in experimental tibial defects in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOzlem Ozmen,Fatma Tomul,Yusuf Sinan SirinPubMed 37551313
- Journal of dental sciences 18:1062-10722023Lidocaine intensifies the anti-osteogenic effect on inflammation-induced human dental pulp stem cells via mitogen-activated protein kinase inhibition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSang-Hoon Lee,Cheul-Hong Kim,Ji-Young Yoon,Eun-Ji Choi,Mi Kyoung Kim,Ji-Uk Yoon,Hee Young Kim,Eun-Jung KimPubMed 37404644
- Stem cell research & therapy 14:1302023Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZijie Wang,Chuying Chen,Jiayi Zhang,Jiangdie He,Lin Zhang,Jiayuan Wu,Zhihui TianPubMed 37189178
- BMC complementary medicine and therapies 23:1292023Panax quinquefolius saponin inhibits vascular smooth muscle cell calcification via activation of nuclear factor-erythroid 2-related factor 2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoting Lu,Xue Liu,Ershun Liang,Ruixue Yang,Yan Liu,Xiaoqiong Liu,Fangfang Yan,Yifan XingPubMed 37085826
- Heliyon 9:e151882023P53 negatively regulates the osteogenic differentiation in jaw bone marrow MSCs derived from diabetic osteoporosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYing Zheng,Junhao Deng,Gang Wang,Xiaru Zhang,Lin Wang,Xiaocao Ma,Yawen Dai,Lingling E,Xiangwei Liu,Rong Zhang,Yi Zhang,Hongchen LiuPubMed 37096002
- The Journal of international medical research 51:30006052311521002023Lidocaine inhibits osteogenic differentiation of human dental pulp stem cells .Applications:Unspecified applicationReactive species:Unspecified reactive speciesEun-Jung Kim,Ji-Uk Yoon,Cheul-Hong Kim,Ji-Young Yoon,Joo-Young Kim,Hyang-Sook Kim,Eun-Ji ChoiPubMed 36748349
- Frontiers in cardiovascular medicine 9:10503102023Role of follistatin-like 1 levels and functions in calcific aortic stenosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQianru Zhang,Jiawen Ye,Gan Yang,Ling Yang,Zhongli Chen,Ke Yang,Jia Teng Sun,Yan LiuPubMed 36684598
- Frontiers in oncology 12:10051522022RRBP1 depletion of bone metastatic cancer cells contributes to enhanced expression of the osteoblastic phenotype.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRui Chen,Yue Wang,Yang Xu,Yaohui He,Qing Li,Chun Xia,Bing ZhangPubMed 36568157
- Pharmaceuticals (Basel, Switzerland) 15:2022Intermedin Alleviates Vascular Calcification in CKD through Sirtuin 3-Mediated Inhibition of Mitochondrial Oxidative Stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShi-Meng Liu,Ya-Rong Zhang,Yao Chen,Deng-Ren Ji,Jie Zhao,Su Fu,Mo-Zhi Jia,Yan-Rong Yu,Chao-Shu Tang,Wei Huang,Ye-Bo Zhou,Yong-Fen QiPubMed 36297336
- Scientific reports 12:159682022FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarja M Hurley,J Douglas Coffin,Thomas Doetschman,Christina Valera,Kai Clarke,Liping XiaoPubMed 36153352
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 30% Glycerol (glycerin, glycerine), 0.75% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Mouse Bmp2 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P21274
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:24362451, PubMed:31019025). Induces cartilage and bone formation (PubMed:3201241). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:16771708, PubMed:20851880). Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity).
Alternative names
BMP2A, BMP2, Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A
Recommended products
Anti-BMP2 antibody (ab14933) is a rabbit polyclonal antibody detecting BMP2 in Western Blot. Suitable for Human.
- Over 170 publications
- Trusted since 2004
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 30% Glycerol (glycerin, glycerine), 0.75% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Mouse Bmp2 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link P21274
- Purification technique
- Affinity purification Immunogen
- Specificity
ab14933 detects only the pro-form of the BMP2
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-BMP2 antibody (ab14933) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB) in Human samples.
Trusted by the scientific community
Anti-BMP2 (ab14933) was first used in a scientific publication in 2004 and has been cited over 170 times in peer-reviewed journals.
Reviewed by scientists
Anti-BMP2 (ab14933) has over 10 independent reviews from customers.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Western blot - Anti-BMP2 antibody (ab14933)
Cell extracts were made in protein extraction buffer (Solobuffer) with protease inhibitor cocktail.
Total 40-50ug of protein was applied in each lane on a 10% SDSPAGE,
The gel was transferred on to Immobilon F and blotted with ab14933.All lanes: Western blot - Anti-BMP2 antibody (ab14933) at 1/500 dilution
Lane 1: HeLa cells
Lane 2: THP cells
Lane 3: HepG2 cells
Lane 4: Huh7 cells
Predicted band size: 44 kDa
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