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AB154373

Anti-BMP8a/OP-2 antibody

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(2 Publications)

Rabbit Polyclonal BMP8a/OP-2 antibody. Suitable for WB, ICC/IF and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Bone morphogenetic protein 8A aa 300 to C-terminus.

View Alternative Names

Bone morphogenetic protein 8A, BMP-8A, BMP8A

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-BMP8a/OP-2 antibody (AB154373)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-BMP8a/OP-2 antibody (AB154373)

Immunofluorescence analysis of paraformaldehyde-fixed mouse ESC D3, labeling BMP8a/OP-2 using ab154373 at 1/200 dilution. Lower panel co-stained with Hoechst 33342.

Western blot - Anti-BMP8a/OP-2 antibody (AB154373)
  • WB

Unknown

Western blot - Anti-BMP8a/OP-2 antibody (AB154373)

7.5% SDS PAGE

All lanes:

Western blot - Anti-BMP8a/OP-2 antibody (ab154373) at 1/500 dilution

Lane 1:

H1299 whole cell lysate at 30 µg

Lane 2:

Raji whole cell lysate at 30 µg

Predicted band size: 45 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human Bone morphogenetic protein 8A aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q7Z5Y6

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Complementary Products

Primary Antibodies

AB183879

Anti-OP-2 antibody

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-F2RL3 antibody - N-terminal (AB188930)

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Primary Antibodies

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Anti-WWOX (phospho Y33) antibody

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  • 0
Primary Antibodies

AB272168

Anti-UBE3A antibody [EPR23077-14]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-UBE3A antibody [EPR23077-14] (AB272168)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.. Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed : 22579288, PubMed : 31940275). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed : 31940275). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed : 31940275).
See full target information Bone morphogenetic protein 8A
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biomarker research 11:46 PubMed37106416

2023

Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia Marañón,Stephania C Isaza,Carlos Ernesto Fernández-García,Esther Rey,Rocío Gallego-Durán,Rocío Montero-Vallejo,Javier Rodríguez de Cía,Javier Ampuero,Ángela M Valverde,Manuel Romero-Gómez,Carmelo García-Monzón,Águeda González-Rodríguez

Cells 8: PubMed31718015

2019

Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Sardar Sindhu,Reeby Thomas,Shihab Kochumon,Ajit Wilson,Mohamed Abu-Farha,Abdullah Bennakhi,Fahd Al-Mulla,Rasheed Ahmad
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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