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AB106085

Anti-bmpA antibody

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(1 Publication)

Rabbit Polyclonal BMPA antibody. Suitable for WB and reacts with Recombinant fragment - Borreliella burgdorferi samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Borreliella burgdorferi B31 bmpA.

View Alternative Names

BB_0383, bmpA, Basic membrane protein A, Immunodominant antigen P39, Probable substrate-binding protein BmpA

1 Images
Western blot - Anti-bmpA antibody (AB106085)
  • WB

Supplier Data

Western blot - Anti-bmpA antibody (AB106085)

4-20% gel.

All lanes:

Western blot - Anti-bmpA antibody (ab106085) at 1/1000 dilution

Lane 1:

MBP-bmpA fusion protein at 0.1 µg

Lane 2:

MBP alone at 0.1 µg

Secondary

All lanes:

Goat-anti-Rabbit HRP at 1/40000 dilution

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Borreliella burgdorferi

Applications

WB

applications

Immunogen

Full Length Protein corresponding to Borreliella burgdorferi B31 bmpA. The exact immunogen used to generate this antibody is proprietary information.

Q45010

Specificity

This antibody is specific for Borrelia burgdorferi p39 protein.  A BLAST analysis was used to suggest cross-reactivity with p39 from B. burgdorferi and B. afzelii sources based on 100% homology with the immunizing sequence.  Partial reactivity is expected against B. garinii sources based on 88-95% homology and to B.spielmanii A14S based on 86-96% homology. Cross-reactivity with p39 from other sources has not been determined.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Borreliella burgdorferi": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Borreliella burgdorferi": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab106085 is cross-adsorbed against MBP from monospecific antiserum by chromatography.
Storage buffer
Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Bacterial membrane protein A often referred to as BmpA is an important surface-exposed lipoprotein found in the outer membrane of Borrelia species. This protein has a molecular mass of approximately 42 kDa. BmpA is expressed in various Borrelia strains making it significant for studies related to Lyme disease. As a lipoprotein its structural characteristics aid in its role as an antigenic component which is frequently utilized in diagnostic assays for detecting Borrelia infections in humans.
Biological function summary

BmpA plays a significant role in the pathogenesis of Borrelia highly influencing the bacteria's ability to invade and persist within the host. It acts as an adhesion molecule assisting the bacteria in attaching to host cells a critical step in infection. Additionally BmpA is involved in the immune evasion strategies of Borrelia allowing the bacteria to survive immune responses. While BmpA itself is not a part of a multi-protein complex it collaborates functionally with other surface proteins to establish infection.

Pathways

BmpA contributes to the mechanism by which Borrelia manipulates host response and establishes persistent infection. The protein is notably involved in the bacterial adhesion pathway that facilitates the binding of Borrelia to extracellular matrix components of the host. BmpA functionally interacts with other surface proteins such as OspA and OspC both important in Borrelia survival and pathogenicity through their roles in immune evasion and adherence.

BmpA is directly linked to Lyme disease one of the most common vector-borne illnesses globally. Borrelia with BmpA as a contributing factor uses this protein for successful colonization and sustenance within the host leading to the characteristic symptoms of Lyme disease. Furthermore autoimmune-like disorders can arise as a result of prolonged infection with BmpA potentially influencing immune dysregulation. In these conditions the interplay between BmpA and other Borrelia antigens like OspA becomes important for understanding disease progression and diagnosis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Immunogenic protein (PubMed : 8050720). May be part of an ABC-type nucleoside uptake system involved in the purine salvage pathway (PubMed : 31988175).
See full target information bmpA

Additional targets

bmpA
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The journal of gene medicine 25:e3552 PubMed37337736

2023

B4GALNT1 promotes carcinogenesis by regulating epithelial-mesenchymal transition in hepatocellular carcinoma based on pan-cancer analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenli Liu,Yutong Chen,Jinqiang Yang,Mingliang Guo,Li Wang
View all publications
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