Anti-bmpA antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Bacterial membrane protein A often referred to as BmpA is an important surface-exposed lipoprotein found in the outer membrane of Borrelia species. This protein has a molecular mass of approximately 42 kDa. BmpA is expressed in various Borrelia strains making it significant for studies related to Lyme disease. As a lipoprotein its structural characteristics aid in its role as an antigenic component which is frequently utilized in diagnostic assays for detecting Borrelia infections in humans.

Biological function summary

BmpA plays a significant role in the pathogenesis of Borrelia highly influencing the bacteria's ability to invade and persist within the host. It acts as an adhesion molecule assisting the bacteria in attaching to host cells a critical step in infection. Additionally BmpA is involved in the immune evasion strategies of Borrelia allowing the bacteria to survive immune responses. While BmpA itself is not a part of a multi-protein complex it collaborates functionally with other surface proteins to establish infection.

Pathways

BmpA contributes to the mechanism by which Borrelia manipulates host response and establishes persistent infection. The protein is notably involved in the bacterial adhesion pathway that facilitates the binding of Borrelia to extracellular matrix components of the host. BmpA functionally interacts with other surface proteins such as OspA and OspC both important in Borrelia survival and pathogenicity through their roles in immune evasion and adherence.

Associated diseases and disorders

BmpA is directly linked to Lyme disease one of the most common vector-borne illnesses globally. Borrelia with BmpA as a contributing factor uses this protein for successful colonization and sustenance within the host leading to the characteristic symptoms of Lyme disease. Furthermore autoimmune-like disorders can arise as a result of prolonged infection with BmpA potentially influencing immune dysregulation. In these conditions the interplay between BmpA and other Borrelia antigens like OspA becomes important for understanding disease progression and diagnosis.