Mouse Monoclonal BMPR1B antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Bone morphogenetic protein receptor type-1B.
Images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR1B antibody [MM0055-3E12] (AB78417), expandable thumbnail](https://content.abcam.com/products/images/bmpr1b-antibody-mm0055-3e12-ab78417--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img88574.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR1B antibody [MM0055-3E12] (AB78417)")
![Western blot - Anti-BMPR1B antibody [MM0055-3E12] (AB78417), expandable thumbnail](https://content.abcam.com/products/images/bmpr1b-antibody-mm0055-3e12-ab78417--western-blot-img96296.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-BMPR1B antibody [MM0055-3E12] (AB78417)")
Publications
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- Cell stem cell 23:599-614.e42018Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMei Wang et. al.PubMed 30174296
- Scientific reports 8:15612018Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLotta Tengroth et. al.PubMed 29367682
- Stem cells translational medicine 6:306-3152017A Selective Cell Population from Dermis Strengthens Bone Regeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTingliang Wang,Jinguang He,Yang Zhang,Wenjun Shi,Jiasheng Dong,Ming Pei,Lian ZhuPubMed 28170187
- Stem cell reports 4:239-542015Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response.Applications:IHC-PReactive species:HumanMarion Chapellier,Elodie Bachelard-Cascales,Xenia Schmidt,Flora Clément,Isabelle Treilleux,Emmanuel Delay,Alexandre Jammot,Christine Ménétrier-Caux,Gaëtan Pochon,Roger Besançon,Thibault Voeltzel,Claude Caron de Fromentel,Christophe Caux,Jean-Yves Blay,Richard Iggo,Véronique Maguer-SattaPubMed 25601208
- Development (Cambridge, England) 140:4751-622013Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development.
- TheScientificWorldJournal 2012:4678922012Immunohistological localization of BMP-2, BMP-7, and their receptors in knee joints with focal cartilage lesions.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHagen Schmal,Alexander T Mehlhorn,Ingo H Pilz,David Dovi-Akue,Christina Kirchhoff,Norbert P Südkamp,Ulrike Gerlach,Christian Lohrmann,Philipp NiemeyerPubMed 22272175
- The Journal of clinical endocrinology and metabolism 96:412-212010Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3.Applications:IHC-PReactive species:HumanDonna C Sinclair,Alex Mastroyannis,Hugh S TaylorPubMed 21084396
Key facts
- Isotype
- IgG2a
- Host species
- Mouse
- Storage buffer
Constituents: PBS
- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human Bone morphogenetic protein receptor type-1B. Database link O00238
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/1000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50 - 1/200 | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Alternative names
CDw293, Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, BMPR1B
Recommended products
Mouse Monoclonal BMPR1B antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Bone morphogenetic protein receptor type-1B.
Key facts
- Isotype
- IgG2a
- Host species
- Mouse
- Storage buffer
Constituents: PBS
- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human Bone morphogenetic protein receptor type-1B. Database link O00238
- Clone number
- MM0055-3E12
- Purification technique
- Affinity purification Protein G
- Specificity
ab78417 detects BMPR1B. No cross reactivity was found to BMPR1A (ALK3).
- Concentration
- Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution inphosphate buffered saline (PBS).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR1B antibody [MM0055-3E12] (ab78417), expandable thumbnail](https://content.abcam.com/products/images/bmpr1b-antibody-mm0055-3e12-ab78417--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img88574.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR1B antibody [MM0055-3E12] (ab78417)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR1B antibody [MM0055-3E12] (ab78417)
ab78417 at 1/200 dilution staining BMPR1B in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).
![Western blot - Anti-BMPR1B antibody [MM0055-3E12] (ab78417), expandable thumbnail](https://content.abcam.com/products/images/bmpr1b-antibody-mm0055-3e12-ab78417--western-blot-img96296.jpg "Western blot - Anti-BMPR1B antibody [MM0055-3E12] (ab78417)")
Western blot - Anti-BMPR1B antibody [MM0055-3E12] (ab78417)
The band observed at 53 kDa could potentially be a cleaved form of BMPR1B due to presence of a 13 amino acid signal peptide.
All lanes: Western blot - Anti-BMPR1B antibody [MM0055-3E12] (ab78417) at 1 µg/mL
Lane 1: Human bone tumor tissue lysate - total protein (ab29359) at 10 µg
Lane 2: WI38 (Human lung fibroblast cell line) Whole Cell Lysate at 10 µg
SecondaryAll lanes: Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (Goat Anti-Mouse IgG H&L (HRP) preadsorbed ab97040) at 1/5000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 57 kDa
Observed band size: 30 kDa, 37 kDa, 50 kDa, 57 kDa
Exposure time: 30s
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