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AB124463

Anti-BMPR2 antibody

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(5 Publications)

Rabbit Polyclonal BMPR2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BMPR2 aa 250-600.

View Alternative Names

PPH1, BMPR2, Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR2 antibody (AB124463)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR2 antibody (AB124463)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fetal liver tissue labelling BMPR2 with ab124463 at a dilution of 1/100.

Western blot - Anti-BMPR2 antibody (AB124463)
  • WB

Unknown

Western blot - Anti-BMPR2 antibody (AB124463)

All lanes:

Western blot - Anti-BMPR2 antibody (ab124463) at 1/500 dilution

All lanes:

Raji cell lysate

Predicted band size: 115 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human BMPR2 aa 250-600. The exact immunogen used to generate this antibody is proprietary information.

Q13873

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed : 12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
See full target information BMPR2
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 6:826 PubMed37558836

2023

Human liver single nuclear RNA sequencing implicates BMPR2, GDF15, arginine, and estrogen in portopulmonary hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Arun Jose,Jean M Elwing,Steven M Kawut,Michael W Pauciulo,Kenneth E Sherman,William C Nichols,Michael B Fallon,Francis X McCormack

Frontiers in oncology 10:542007 PubMed33123465

2020

Targeting 14-3-3ζ Overcomes Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Lung Adenocarcinoma via BMP2/Smad/ID1 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jinfang Cui,Yang Song,Xuejiao Han,Jing Hu,Yanbo Chen,Xuesong Chen,Xiaomin Xu,Ying Xing,Hailing Lu,Li Cai

Cell reports 31:107570 PubMed32348751

2020

Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Sayantani Sinha,Mayukh Biswas,Shankha Subhra Chatterjee,Sanjay Kumar,Amitava Sengupta

Neural development 11:4 PubMed26878848

2016

Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.

Applications

ICC

Species

Unspecified reactive species

Gerard W O'Keeffe,Humberto Gutierrez,Laura Howard,Christopher W Laurie,Catarina Osorio,Núria Gavaldà,Sean L Wyatt,Alun M Davies

Development (Cambridge, England) 140:4751-62 PubMed24173804

2013

Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development.

Applications

ICC/IF

Species

Mouse

Catarina Osório,Pedro J Chacón,Lilian Kisiswa,Matthew White,Sean Wyatt,Alfredo Rodríguez-Tébar,Alun M Davies
View all publications
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