Rabbit Polyclonal BMPR2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BMPR2 aa 650-950.
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- Frontiers in cell and developmental biology 11:11589362023Establishing and characterizing human stem cells from the apical papilla immortalized by hTERT gene transfer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQianyu Cheng,Chang Liu,Qiuman Chen,Wenping Luo,Tong-Chuan He,Deqin YangPubMed 37283947
- International journal of biological sciences 18:572-5842022Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuan Xue,Sihan Hu,Chichi Chen,Jiachen He,Jie Sun,Yesheng Jin,Yuanshu Zhang,Guoqing Zhu,Qin Shi,Yongjun RuiPubMed 35002510
- International journal of biological sciences 17:2367-23792021Recombinant human bone morphogenetic protein 2 and 7 inhibit the degeneration of intervertebral discs by blocking the Puma-dependent apoptotic signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShiwei Xie,Chenyang Zhao,Wei Chen,Gengwu Li,Zhiwei Xiong,Xiangjun Tang,Fan Zhang,Heng XiaoPubMed 34239363
- Stem cell research & therapy 11:4722020Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKyeoung-Hwa Kim et. al.PubMed 33153492
- Journal of cellular physiology 234:21316-213302019LOC103691336/miR-138-5p/BMPR2 axis modulates Mg-mediated osteogenic differentiation in rat femoral fracture model and rat primary bone marrow stromal cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDing Li et. al.PubMed 31081160
- Cell death & disease 9:9242018Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYanli Xu,Xinlong Luo,Zhuoqing Fang,Xiaofeng Zheng,Yanwu Zeng,Chaonan Zhu,Junjie Gu,Fan Tang,Yanqin Hu,Guang Hu,Ying Jin,Hui LiPubMed 30206204
- Arteriosclerosis, thrombosis, and vascular biology 38:1821-18362018BMP9 (Bone Morphogenetic Protein-9)/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNaoufal Akla,Claire Viallard,Natalija Popovic,Cindy Lora Gil,Przemyslaw Sapieha,Bruno LarrivéePubMed 29880487
- Toxicological sciences : an official journal of the Society of Toxicology 159:137-1582017From the Cover: Arsenic Induces Hippocampal Neuronal Apoptosis and Cognitive Impairments via an Up-Regulated BMP2/Smad-Dependent Reduced BDNF/TrkB Signaling in Rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRukmani Pandey,Vipin Rai,Juhi Mishra,Kapil Mandrah,Somendu Kumar Roy,Sanghamitra BandyopadhyayPubMed 28903487
- American journal of physiology. Lung cellular and molecular physiology 310:L187-2012015Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.Applications:ICC/IFReactive species:HumanKeytam S Awad,Jason M Elinoff,Shuibang Wang,Salina Gairhe,Gabriela A Ferreyra,Rongman Cai,Junfeng Sun,Michael A Solomon,Robert L DannerPubMed 26589479
- Development (Cambridge, England) 140:4751-622013Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human BMPR2 aa 650-950. The exact immunogen used to generate this antibody is proprietary information. Database link Q13873
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Expected |
| Mouse | Tested | Expected |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Associated Products
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3 products for Alternative Product
Target data
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Alternative names
PPH1, BMPR2, Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II
Recommended products
Rabbit Polyclonal BMPR2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BMPR2 aa 650-950.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 78% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human BMPR2 aa 650-950. The exact immunogen used to generate this antibody is proprietary information. Database link Q13873
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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3 product images
Western blot - Anti-BMPR2 antibody (ab96826)
7.5% SDS-PAGE
All lanes: Western blot - Anti-BMPR2 antibody (ab96826) at 1/1000 dilution
Lane 1: H1299 whole cell lysate at 30 µg
Lane 2: Raji whole cell lysate at 30 µg
Predicted band size: 115 kDa
Western blot - Anti-BMPR2 antibody (ab96826)
7.5% SDS-PAGE
All lanes: Western blot - Anti-BMPR2 antibody (ab96826) at 1/1000 dilution
All lanes: NIH-3T3 whole cell lysate at 30 µg
Predicted band size: 115 kDa
Image collected and cropped by CiteAb under a CC-BY license from the publication
Western blot - Anti-BMPR2 antibody (ab96826)
BMPR2 western blot using anti-BMPR2 antibody ab96826. Publication image and figure legend from Xu, Y., Luo, X., et al., 2018, Cell Death Dis, PubMed 30206204.
ab96826 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab96826 please see the product overview.
Cited1 interacts with Bmpr2 to activate BMP signaling and induce trophoblast differentiation.a Protein levels of pSmad1/5 and pSmad2 upon Cited1 overexpression in E14T ESCs at the times as indicated. Smad5, Smad2/3, and α-Tubulin were used as loading controls. b Protein levels of pSmad1/5 and pSmad2 upon Cited1 overexpression and inhibitor treatment for 3 days in E14T ESCs. Smad5, Smad2/3, and α-Tubulin were used as loading controls. c Bright field images of Cited1-overexpressing or control ESCs after treatment with DMSO or different inhibitors for 3 days. LDN193189 (0.1 μM), Noggin (400 ng/mL) and K02288 (10 μM) are all BMP signaling inhibitors. SB431542 (10 μM) is a TGF-β signaling inhibitor. d qRT-PCR analysis of transcript levels of trophoblast markers after transfection and treatment with inhibitors for 3 days. The average mRNA level in cells transfected with control vector pPy and treated with DMSO was set at 1.0. Data are shown as mean ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001. e qRT-PCR analysis of mRNA levels for ligands of the BMP pathway induced by Cited1 overexpression in E14T ESCs for 3 days. The average mRNA level in cells transfected with control vector pPy was set at 1.0. Data are shown as mean ± SD (n = 3). *p < 0.05. f The representative western blot result from Co-IP (immunoprecipitation) assays showing that ectopically expressed Flag-Cited1 binds to endogenous Bmpr2 specifically in E14T ESCs. Whole-cell lysates (WCL) were immunoprecipitated with anti-Flag M2 beads and analyzed by western blot with antibodies as indicated. Five percent of WCL was loaded as the input. g qRT-PCR analysis of mRNA levels of trophoblast specific markers in parental WT ESCs or Bmpr2 knockout (KO) cells upon Cited1 overexpression for 3 days. The average mRNA level in WT cells transfected with empty vector pPy was set at 1.0. Data are shown as mean ± SD (n = 3). ***p < 0.001
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