AB137718

Anti-Bone marrow stromal cell antigen 1 antibody

Name: Anti-Bone marrow stromal cell antigen 1 antibody (ab137718) | Abcam
Brand: Abcam Limited
SKU: AB137718
Price: 535 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal Bone marrow stromal cell antigen 1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BST1 aa 1-150.

View Alternative Names

CD157, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, Bone marrow stromal cell antigen 1, Cyclic ADP-ribose hydrolase 2, BST-1, cADPR hydrolase 2, BST1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bone marrow stromal cell antigen 1 antibody (AB137718)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bone marrow stromal cell antigen 1 antibody (AB137718)

Immunohistochemical analysis of paraffin-embedded SW480 xenograft labelling Bone marrow stromal cell antigen 1 with ab137718 at 1/100 dilution.

Unknown

Western blot - Anti-Bone marrow stromal cell antigen 1 antibody (AB137718)

10% SDS PAGE

All lanes:

Western blot - Anti-Bone marrow stromal cell antigen 1 antibody (ab137718) at 1/500 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 36 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human BST1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q10588

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Perform heat mediated antigen retrieval using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) before commencing with IHC staining protocol.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Bone marrow stromal cell antigen 1 (BST-1) also known as CD157 is a glycosylphosphatidylinositol-anchored protein with a molecular weight of approximately 38-42 kDa. You find BST-1 expression on the surface of various cell types especially within bone marrow stromal cells and cells of the immune system such as monocytes and macrophages. This protein functions as an ecto-enzyme with ADP-ribosyl cyclase activity and is part of the NADase enzyme family. Its mechanical role involves metabolizing extracellular NAD+ influencing cellular calcium signaling and energy metabolism.

Biological function summary

BST-1 contributes to the regulation of cellular interactions and immune responses. It participates in the organization of leukocyte trafficking and the formation of signal transduction cascades. BST-1 operates as a single protein but interacts with other membrane proteins to coordinate cellular communication. You can observe its function in processes like cell adhesion and migration impacting the immune surveillance and response systems.

Pathways

BST-1 plays a role in immune signaling and calcium-signaling pathways. In the immune system pathway it associates with molecules such as integrins to modulate leukocyte adhesion and transmigration. The calcium-signaling pathway is another key area where BST-1 interacts with intracellular proteins influencing various cellular targets and affecting metabolic processes critical for cell survival and proliferation.

Scientists have linked BST-1 to various conditions such as leukemia and chronic inflammation. Its expression levels often change in these diseases emphasizing its potential role in their progression. Researchers also explore the connection between BST-1 and other proteins like CD38 in the context of leukemia where both proteins might participate in cancer cell proliferation and survival. Understanding BST-1 in disease contexts provides insights into disease mechanisms and potential therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed : 7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).

See full target information BST1

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:1932 PubMed39994201

2025

Anti-PD1 based precision induction therapy in unresectable stage III non-small cell lung cancer: a phase II umbrella clinical trial.

Applications

Unspecified application

Species

Unspecified reactive species

Chengxiang Yi,Dongliang Bian,Jue Wang,Shiqi Hu,Liangdong Sun,Yilv Yan,Suyu Wang,Ziyun Shen,Huansha Yu,Yong Yang,Yirui Zhou,Xiaogang Liu,Nan Song,Yuming Zhu,Deping Zhao,Gening Jiang,Liang Duan,Wenxin He,Dong Xie,Jie Dai,Lele Zhang,Peng Zhang

mBio 10: PubMed31455656

2019

CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.

Applications

Unspecified application

Species

Unspecified reactive species

Qianting Yang,Mingfeng Liao,Wenfei Wang,Mingxia Zhang,Qi Chen,Jiubiao Guo,Bin Peng,Jian Huang,Haiying Liu,Ayano Yahagi,Xingzhi Xu,Katsuhiko Ishihara,Andrea Cooper,Xinchun Chen,Yi Cai

Autism research : official journal of the Internat 7:254-63 PubMed24634087

2014

A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Fabiola Ceroni,Angela Sagar,Nuala H Simpson,Alex J T Gawthrope,Dianne F Newbury,Dalila Pinto,Sunday M Francis,Dorothy C Tessman,Edwin H Cook,Anthony P Monaco,Elena Maestrini,Alistair T Pagnamenta,Suma Jacob

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Bone marrow stromal cell antigen 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bone marrow stromal cell antigen 1 antibody (AB137718)

Western blot - Anti-Bone marrow stromal cell antigen 1 antibody (AB137718)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise