Rabbit Polyclonal Bone marrow stromal cell antigen 1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BST1 aa 1-150.
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- mBio 10:2019CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQianting Yang et. al.PubMed 31455656
- Autism research : official journal of the Internat 7:254-632014A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFabiola Ceroni et. al.PubMed 24634087
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human BST1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q10588
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes Perform heat mediated antigen retrieval using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) before commencing with IHC staining protocol. |
Associated Products
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Target data
Function
Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).
Alternative names
CD157, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, Bone marrow stromal cell antigen 1, Cyclic ADP-ribose hydrolase 2, BST-1, cADPR hydrolase 2, BST1
Recommended products
Rabbit Polyclonal Bone marrow stromal cell antigen 1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BST1 aa 1-150.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human BST1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q10588
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Bone marrow stromal cell antigen 1 (BST-1) also known as CD157 is a glycosylphosphatidylinositol-anchored protein with a molecular weight of approximately 38-42 kDa. You find BST-1 expression on the surface of various cell types especially within bone marrow stromal cells and cells of the immune system such as monocytes and macrophages. This protein functions as an ecto-enzyme with ADP-ribosyl cyclase activity and is part of the NADase enzyme family. Its mechanical role involves metabolizing extracellular NAD+ influencing cellular calcium signaling and energy metabolism.
- Biological function summary
BST-1 contributes to the regulation of cellular interactions and immune responses. It participates in the organization of leukocyte trafficking and the formation of signal transduction cascades. BST-1 operates as a single protein but interacts with other membrane proteins to coordinate cellular communication. You can observe its function in processes like cell adhesion and migration impacting the immune surveillance and response systems.
- Pathways
BST-1 plays a role in immune signaling and calcium-signaling pathways. In the immune system pathway it associates with molecules such as integrins to modulate leukocyte adhesion and transmigration. The calcium-signaling pathway is another key area where BST-1 interacts with intracellular proteins influencing various cellular targets and affecting metabolic processes critical for cell survival and proliferation.
- Associated diseases and disorders
Scientists have linked BST-1 to various conditions such as leukemia and chronic inflammation. Its expression levels often change in these diseases emphasizing its potential role in their progression. Researchers also explore the connection between BST-1 and other proteins like CD38 in the context of leukemia where both proteins might participate in cancer cell proliferation and survival. Understanding BST-1 in disease contexts provides insights into disease mechanisms and potential therapeutic strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-Bone marrow stromal cell antigen 1 antibody (ab137718)
10% SDS PAGE
All lanes: Western blot - Anti-Bone marrow stromal cell antigen 1 antibody (ab137718) at 1/500 dilution
All lanes: Raji whole cell lysate at 30 µg
Predicted band size: 36 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bone marrow stromal cell antigen 1 antibody (ab137718)
Immunohistochemical analysis of paraffin-embedded SW480 xenograft labelling Bone marrow stromal cell antigen 1 with ab137718 at 1/100 dilution.
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