AB92395

Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5]

Name: Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5] (ab92395) | Abcam
Brand: Abcam Limited
SKU: AB92395
Price: 535 USD
Availability: InStock

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(2 Publications)

Mouse Monoclonal Bone marrow stromal cell antigen 1 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human BST1.

View Alternative Names

CD157, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, Bone marrow stromal cell antigen 1, Cyclic ADP-ribose hydrolase 2, BST-1, cADPR hydrolase 2, BST1

2 Images

Flow Cytometry - Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5] (AB92395)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5] (AB92395)

Flow cytometry analysis labelling normal human peripheral blood cells with Mouse IgG1 K Isotype Control Purified (left) or ab92395 (right) at 0.25 μg, followed by F (ab')2 Anti-Mouse IgG PE.

Flow Cyt

Unknown

Flow Cytometry - Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5] (AB92395)

Staining of normal human peripheral blood cells with ab92395 at 0.25 µg (blue histogram), or purified Mouse IgG1k, isotype control at 0.25 µg (green histogram), followed by treatment with FITC anti-mouse IgG. Cells in the monocyte gate were used for analysis.

519 FITC

FITC Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5]
660 APC

APC Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SY11B5

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Native Full Length Protein corresponding to Human BST1.

Q10588

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.5 µg for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Bone marrow stromal cell antigen 1 (BST-1) also known as CD157 is a glycosylphosphatidylinositol-anchored protein with a molecular weight of approximately 38-42 kDa. You find BST-1 expression on the surface of various cell types especially within bone marrow stromal cells and cells of the immune system such as monocytes and macrophages. This protein functions as an ecto-enzyme with ADP-ribosyl cyclase activity and is part of the NADase enzyme family. Its mechanical role involves metabolizing extracellular NAD+ influencing cellular calcium signaling and energy metabolism.

Biological function summary

BST-1 contributes to the regulation of cellular interactions and immune responses. It participates in the organization of leukocyte trafficking and the formation of signal transduction cascades. BST-1 operates as a single protein but interacts with other membrane proteins to coordinate cellular communication. You can observe its function in processes like cell adhesion and migration impacting the immune surveillance and response systems.

Pathways

BST-1 plays a role in immune signaling and calcium-signaling pathways. In the immune system pathway it associates with molecules such as integrins to modulate leukocyte adhesion and transmigration. The calcium-signaling pathway is another key area where BST-1 interacts with intracellular proteins influencing various cellular targets and affecting metabolic processes critical for cell survival and proliferation.

Scientists have linked BST-1 to various conditions such as leukemia and chronic inflammation. Its expression levels often change in these diseases emphasizing its potential role in their progression. Researchers also explore the connection between BST-1 and other proteins like CD38 in the context of leukemia where both proteins might participate in cancer cell proliferation and survival. Understanding BST-1 in disease contexts provides insights into disease mechanisms and potential therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed : 7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable).

See full target information BST1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 21:434 PubMed33747173

2021

Effect of TNF-α on the proliferation and osteogenesis of human periodontal mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yiting Cao,Yiwei Wang,Chenlin Li,Qian Jiang,Laikuan Zhu

Biomedicines 9: PubMed33562346

2021

The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin.

Applications

Unspecified application

Species

Unspecified reactive species

Eiji Kawamoto,Nodoka Nago,Takayuki Okamoto,Arong Gaowa,Asami Masui-Ito,Yuichi Akama,Samuel Darkwah,Michael Gyasi Appiah,Phyoe Kyawe Myint,Gideon Obeng,Atsushi Ito,Siqingaowa Caidengbate,Ryo Esumi,Takanori Yamaguchi,Eun Jeong Park,Hiroshi Imai,Motomu Shimaoka

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5]

Flow Cytometry - Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5] (AB92395)

Flow Cytometry - Anti-Bone marrow stromal cell antigen 1 antibody [SY11B5] (AB92395)

Related conjugates and formulations (2)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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