Anti-Bovine Coronavirus [2B8]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Bovine Coronavirus Nucleoprotein (N) which is also known as the nucleocapsid protein plays an important role in the viral replication and transcription cycle. This protein weighing approximately 50 kDa serves multiple functions including packaging the viral RNA genome into a ribonucleoprotein complex. It is highly conserved and predominantly found within the infected cells where the Bovine Coronavirus is present.

Biological function summary

The Bovine Coronavirus Nucleoprotein interacts aggressively with viral RNA and other viral proteins to facilitate efficient virus assembly and egress. It forms part of a complex with the viral membrane (M) protein supporting virion structure and stability. By binding specifically to the viral RNA it protects the RNA from degradation therefore ensuring viral replication occurs effectively within the host cell.

Pathways

The Bovine Coronavirus Nucleoprotein plays a role in virus assembly and replication pathways contributing to the production of viral components necessary for successful infection propagation. It is closely linked with the M protein through these pathways helping maintain the structural integrity of the virion. Additionally it interacts with host cellular pathways affecting the host cell's protein synthesis machinery facilitating viral replication over host processes.

Associated diseases and disorders

The Bovine Coronavirus Nucleoprotein is critically linked to bovine respiratory and enteric infections commonly associated with calf diarrhea and winter dysentery in adult cattle. It shows interactions with other viral proteins such as the spike (S) protein which plays a role in the virus's ability to infect host cells. Better understanding this nucleoprotein and its associated pathways can be pivotal for developing effective treatments and preventive measures against these veterinary diseases.