Rabbit Recombinant Monoclonal BRD7 antibody. Suitable for Flow Cyt, ICC, IHC-P, IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human BRD7 aa 600 to C-terminus.
Images
![Flow Cytometry - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--flow-cytometry-img420377.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048)")
![Immunocytochemistry - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--immunocytochemistry-img420380.jpg/_jcr_content/renditions/webp-475.webp "Immunocytochemistry - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img420379.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048)")
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img420378.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (AB314048)")
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.8 - 8.6
Preservative: 0.09% Sodium azide
Constituents: 98% Borate buffered saline- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Synthetic Peptide within Human BRD7 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NPI1
Reactivity data
Select an application| Flow Cyt | ICC | IHC-P | IP | WB | |
|---|---|---|---|---|---|
| Human | Tested | Tested | Tested | Tested | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Target data
Function
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
Alternative names
BP75, CELTIX1, BRD7, Bromodomain-containing protein 7, 75 kDa bromodomain protein, Protein CELTIX-1
Recommended products
Rabbit Recombinant Monoclonal BRD7 antibody. Suitable for Flow Cyt, ICC, IHC-P, IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human BRD7 aa 600 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.8 - 8.6
Preservative: 0.09% Sodium azide
Constituents: 98% Borate buffered saline- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Synthetic Peptide within Human BRD7 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NPI1
- Clone number
- BLR221K
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 12 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
4 product images
![Flow Cytometry - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--flow-cytometry-img420377.jpg "Flow Cytometry - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)")
Flow Cytometry - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)
Antibody:Rabbit anti-BRD7 recombinant monoclonal antibody [BLR221K] or isotype control (unshaded). Secondary:DyLight® 650-conjugated goat anti-rabbit IgG
![Immunocytochemistry - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--immunocytochemistry-img420380.jpg "Immunocytochemistry - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)")
Immunocytochemistry - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)
Sample:FFPE section of RKO cells. Antibody:Rabbit antiBRD7 recombinant monoclonal antibody [BLR221K] Secondary:HRP-conjugated goat antirabbit IgG
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img420379.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)
Sample:FFPE section of human testis. Antibody:Rabbit anti-BRD7 recombinant monoclonal antibody [BLR221K] (A700-221-1). Secondary:HRP-conjugated goat antirabbit IgG (A120-501P).
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048), expandable thumbnail](https://content.abcam.com/products/images/brd7-antibody-blr221k-bsa-free-ab314048--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img420378.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BRD7 antibody [BLR221K] - BSA free (ab314048)
Sample:FFPE section of prostate carcinoma. Antibody: Rabbit anti-BRD7 recombinant monoclonal antibody [BLR221K]. Secondary:HRP-conjugated goat anti-rabbit IgG
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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