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AB50991

Anti-BTG1 antibody [2095C1a]

3

(2 Reviews)

|

(2 Publications )

Mouse Monoclonal BTG1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2095C1a

Isotype

IgG1

Carrier free

No

Applications

WB

applications

Specificity

ab50991 has not yet been tested on endogenous protein in cell lysate.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

BTG1 also known as B-cell translocation gene 1 protein is a member of the BTG/TOB family. This protein generally serves a role in cell cycle regulation by acting as an antiproliferative agent. BTG1 has an approximate mass of 22 kDa. Its expression is mainly found in the hematopoietic system with notable presence in the lymphoid tissues suggesting a significant role in immune system functionality.
Biological function summary

BTG1 affects fundamental cellular processes through its interaction with other proteins. This protein plays a role in cell cycle regulation by influencing key processes like proliferation differentiation and apoptosis. BTG1 functions as part of a complex that involves interactions with CCR4-NOT transcription complex and various growth regulators. These engagements highlight the multifaceted roles of BTG1 in cell regulation.

Pathways

BTG1 plays an important role in the regulation of cellular growth and differentiation pathways. It interfaces with key players such as cyclin D1 and p53 both important for cell cycle progression and DNA damage response pathways. These interactions position BTG1 within the broader regulatory network of cell cycle control maintaining cellular growth homeostasis and preventing unregulated proliferation.

BTG1 involvement has been observed in certain types of cancer particularly leukemia. Its expression levels can indicate the progression or prognosis of such malignancies. BTG1 often shows altered expression levels in conjunction with proteins like B-cell lymphoma 2 (Bcl-2) in the context of hematological disorders. Understanding BTG1 interactions provides valuable insight into potential therapeutic targets for managing these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Anti-proliferative protein.
See full target information Protein BTG1

Alternative Names

Protein BTG1, B-cell translocation gene 1 protein, BTG1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

European journal of immunology 51:103-114 PubMed32652569

2020

The E3 ubiquitin ligase Itch deficiency promotes antigen-driven B-cell responses in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Fang,Youdi He,Bing Zhai,Chunmei Hou,Ruonan Xu,Chen Xing,Xiaoqian Wang,Ning Ma,Gencheng Han,Renxi Wang

Oncology letters 10:619-624 PubMed26622543

2015

BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma by interacting with PRMT1.

Applications

WB, IHC

Species

Unspecified reactive species, Unspecified reactive species

Chunhui Liu,Tao Tao,Bin Xu,Kai Lu,Lei Zhang,Liang Jiang,Shuqiu Chen,Dachuang Liu,Xiaowen Zhang,Nihao Cao,Ming Chen
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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