Rabbit Polyclonal BZW2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human BZW2 aa 1-250.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | ICC/IF | |
---|---|---|
Human | Tested | Tested |
Mouse | Predicted | Predicted |
Rat | Predicted | Predicted |
Cow | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/200.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Cow | Dilution info - | Notes - |
Select an associated product type
Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931).
5MP1, HSPC028, MSTP017, BZW2, eIF5-mimic protein 1, Basic leucine zipper and W2 domain-containing protein 2
Rabbit Polyclonal BZW2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human BZW2 aa 1-250.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
BZW2 also known as Basic Leucine Zipper and W2 Domain-Containing Protein 2 is a leucine zipper protein involved in the regulation of translation. It has other names like HSPC017 and 25FL. The molecular weight of BZW2 is approximately 46 kDa. This protein is expressed in various tissues with high levels in the pancreas and placenta. Its key mechanical role involves interacting with ribosomal subunits to modulate translation initiation particularly under conditions that require altered protein synthesis rates.
Several critical roles situate BZW2 in cellular growth and proliferation. It acts as a translation regulator and integrates into ribosomal complexes during the protein synthesis process. BZW2 augments the synthesis of proteins by accelerating the assembly of initiation complexes. Furthermore BZW2 indirectly affects cell cycle progression by coordinating with other translational regulators. Its expression levels correlate with rapidly dividing tissues hinting at its role in growth and development.
BZW2 plays an integral part in the mTOR signaling pathway and the integrated stress response (ISR) pathway. In the mTOR pathway BZW2 collaborates with other initiation factors to enhance protein synthesis related to cellular growth. Within the ISR it adjusts protein translation in response to cellular stress maintaining balance in protein homeostasis. BZW2's interaction with proteins like eIF2α highlights its significance in translational control during stress conditions.
Alterations in BZW2 expression relate to cancer and neurodegenerative disorders. Abnormal regulation of BZW2 can lead to increased cell proliferation linking it to cancer development particularly in aggressive tumor types. It also connects with proteins like p53 in cancer pathways affecting apoptosis. Additionally dysfunction in the ISR involving BZW2 has implications in neurodegenerative diseases potentially through its role in stress response and protein folding affecting neuronal survival.
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10% SDS-PAGE
All lanes: Western blot - Anti-BZW2 antibody (ab96682) at 1/1000 dilution
Lane 1: A431 whole cell lysate at 30 µg
Lane 2: HeLa S3 whole cell lysate at 30 µg
Lane 3: MOLT4 whole cell lysate at 30 µg
Predicted band size: 48 kDa
ab96682, at 1/200 dilution, staining BZW2 in paraformaldehyde-fixed HeLa cells by Immunofluorescence. Lower image is merged with DNA probe.
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