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AB31367

Anti-c-Jun antibody

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(5 Publications)

Rabbit Polyclonal c-Jun antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human JUN.

View Alternative Names

Transcription factor Jun, Activator protein 1, Proto-oncogene c-Jun, Transcription factor AP-1 subunit Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, AP1, JUN

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Jun antibody (AB31367)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Jun antibody (AB31367)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma labeling c-Jun with ab31367 at 1/100. Left : c-Jun antibody, Right : Preincubated with synthesized peptide.

Western blot - Anti-c-Jun antibody (AB31367)
  • WB

Unknown

Western blot - Anti-c-Jun antibody (AB31367)

All lanes:

Western blot - Anti-c-Jun antibody (ab31367) at 1/1000 dilution

Lane 1:

HeLa cells lysate, preincubated with immunogen (synthetic non-phosphopeptide)

Lane 2:

HeLa cells lysate

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human JUN. The exact immunogen used to generate this antibody is proprietary information.

P05412

Specificity

ab31367 detects endogenous levels of c-Jun protein around Serine 73.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein c-Jun is an important component of the AP-1 transcription factor complex and is often referred to by alternative names such as c-jun. It has a molecular weight of about 39 kDa. Scientists have found c-jun expressed in a wide range of tissues indicating its diverse roles in cellular functions. This protein plays a critical mechanical role by binding specific DNA sequences to regulate the transcription of various genes involved in cell proliferation and apoptosis.
Biological function summary

C-Jun impacts cellular activities by being a significant part of the AP-1 transcription factor complex interacting with other proteins such as Fos. This interaction allows c-Jun to modulate gene expression in response to cellular stimuli. In particular c-Jun influences cell cycle progression and differentiation. Therefore its activity is necessary for physiological and pathological processes. As c-jun's function remains tightly regulated any changes can have wide-ranging effects.

Pathways

C-Jun significantly influences the MAPK/ERK and JNK pathways. These pathways play important roles in cellular responses to stress growth factors and cytokines. Within these pathways c-Jun interacts with proteins such as JNK which phosphorylates c-Jun and enhances its activity. These interactions allow c-Jun to regulate target genes involved in important cellular processes without much delay. Understanding c-Jun's function in these pathways helps elucidate how cells control division survival and apoptosis.

C-Jun's dysregulation connects to various conditions including cancer and neurodegenerative diseases. Abnormal c-Jun activity can lead to oncogenesis by promoting unrestrained cellular proliferation. Additionally c-Jun involvement in disorders like Alzheimer's disease stems from its role in apoptotic pathways which may cause neuronal death. Accompanying proteins like JNK are also implicated in these conditions making the regulation and expression of c-Jun a focus for therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed : 10995748, PubMed : 22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed : 12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed : 17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed : 24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed : 24623306).. (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression.
See full target information JUN
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Aging 16:7043-7059 PubMed38637111

2024

Identification of biomarkers and immune infiltration characterization of lipid metabolism-associated genes in osteoarthritis based on machine learning algorithms.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanye Ma,Yang Liu,Dan Luo,Zhu Guo,Hongfei Xiang,Bohua Chen,Xiaolin Wu

Molecular therapy. Nucleic acids 21:428-440 PubMed32668390

2020

Overexpression of microRNA-203 Suppresses Proliferation, Invasion, and Migration while Accelerating Apoptosis of CSCC Cell Line SCL-1.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyun Ting,Cheng Feng,Mingzi Zhang,Fei Long,Ming Bai

Cancer cell 31:771-789.e6 PubMed28609656

2017

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Applications

Unspecified application

Species

Unspecified reactive species

Detian Yuan,Shan Huang,Emanuel Berger,Lei Liu,Nina Gross,Florian Heinzmann,Marc Ringelhan,Tracy O Connor,Mira Stadler,Michael Meister,Julia Weber,Rupert Öllinger,Nicole Simonavicius,Florian Reisinger,Daniel Hartmann,Rüdiger Meyer,Maria Reich,Marco Seehawer,Valentina Leone,Bastian Höchst,Dirk Wohlleber,Simone Jörs,Marco Prinz,Duncan Spalding,Ulrike Protzer,Tom Luedde,Luigi Terracciano,Matthias Matter,Thomas Longerich,Percy Knolle,Thomas Ried,Verena Keitel,Fabian Geisler,Kristian Unger,Einat Cinnamon,Eli Pikarsky,Norbert Hüser,Roger J Davis,Darjus F Tschaharganeh,Roland Rad,Achim Weber,Lars Zender,Dirk Haller,Mathias Heikenwalder

PLoS computational biology 8:e1002511 PubMed22615549

2012

Google goes cancer: improving outcome prediction for cancer patients by network-based ranking of marker genes.

Applications

IHC-Fr

Species

Human

Christof Winter,Glen Kristiansen,Stephan Kersting,Janine Roy,Daniela Aust,Thomas Knösel,Petra Rümmele,Beatrix Jahnke,Vera Hentrich,Felix Rückert,Marco Niedergethmann,Wilko Weichert,Marcus Bahra,Hans J Schlitt,Utz Settmacher,Helmut Friess,Markus Büchler,Hans-Detlev Saeger,Michael Schroeder,Christian Pilarsky,Robert Grützmann

The Journal of biological chemistry 283:31949-59 PubMed18753129

2008

Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions.

Applications

IHC-P

Species

Mouse

Willis K Samson,Jian V Zhang,Orna Avsian-Kretchmer,Kai Cui,Gina L C Yosten,Cindy Klein,Rong-Ming Lyu,Yong Xiong Wang,Xiang Qun Chen,Jun Yang,Christopher J Price,Ted D Hoyda,Alastair V Ferguson,Xiao-bin Yuan,Jaw Kang Chang,Aaron J W Hsueh
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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