Anti-c-Kit antibody [KIT/982] - BSA and Azide free
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(1 Publication)
Mouse Monoclonal c-Kit antibody. Carrier free. Suitable for WB, Protein Array and reacts with Recombinant fragment - Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KIT aa 100-300.
View Alternative Names
CD117, SCFR, KIT, Mast/stem cell growth factor receptor Kit, Piebald trait protein, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PBT
- Protein Array
Unknown
Protein Array - Anti-c-Kit antibody [KIT/982] - BSA and Azide free (AB212519)
This data was produced with ab233902, the same antibody in a different formulation with BSA and Azide.
ab233902 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
- WB
Supplier Data
Western blot - Anti-c-Kit antibody [KIT/982] - BSA and Azide free (AB212519)
All lanes:
Western blot - Anti-c-Kit antibody [KIT/982] - BSA and Azide free (ab212519) at 1 µg/mL
All lanes:
recombinant fragment of Human c-Kit
Predicted band size: 109 kDa,26 kDa
false
Reactivity data
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
C-Kit influences the function and survival of certain cell types. When it binds to its ligand stem cell factor (SCF) it activates receptor dimerization and phosphorylation triggering downstream signaling. C-Kit does not act alone; it often functions in a complex with other proteins to affect cellular outcomes. Its expression is vital for the maintenance of bone marrow hematopoietic cells and contributes to melanocyte and germ cell development.
Pathways
C-Kit interacts with the PI3K/AKT and RAS/ERK pathways through its kinase activity. These pathways play important roles in cell division differentiation and survival. The c-Abl and ACK2 proteins are closely related to c-Kit function within these signaling networks contributing to regulating cellular responses to external stimuli.
Product protocols
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Target data
Publications (1)
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The EMBO journal 39:e103790 PubMed32567735
2020
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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