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AB17355

Anti-c-Myc antibody [8]

5

(6 Reviews)

|

(11 Publications)

Mouse Monoclonal C-Myc/MYC antibody. Suitable for IHC-P and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYC.

View Alternative Names

BHLHE39, MYC, Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, Proto-oncogene c-Myc, Transcription factor p64, bHLHe39

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [8] (AB17355)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [8] (AB17355)

Immunohistochemistry of kidney tissue using ab17355 at 10 μg/ml.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

8

Isotype

IgG2a

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MYC.

P01106

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.08% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C-Myc also known simply as Myc or MYC protein is a transcription factor with significant roles in cellular processes. Its estimated molecular weight is approximately 62 kDa. This protein is expressed in various tissues and cell types including common use in HEK (human embryonic kidney) cells for research. c-Myc functions by regulating transcription of genes involved in cell cycle progression apoptosis and cellular transformation.
Biological function summary

C-Myc is involved in regulating cell growth and proliferation. It forms part of the Myc/Max complex which binds to DNA to regulate gene expression. This activity affects cellular metabolism ribosome biogenesis and cell cycle entry emphasizing its regulation of cellular energy and stress response. Its expression levels critically govern normal cellular functions and homeostasis.

Pathways

C-Myc plays an important role in the cell cycle pathway and apoptosis regulation. Specifically c-Myc is associated with the Wnt signaling pathway which influences cellular proliferation and differentiation. It also interacts with other proteins like Cyclin D1 influencing cell cycle control. These interactions ensure c-Myc's involvement in regulating key processes related to cell proliferation and stability.

C-Myc is tightly linked to cancer such as Burkitt's lymphoma and colon cancer. In these conditions c-Myc overexpression contributes to uncontrolled cell proliferation. Additionally c-Myc is associated with other oncogenic proteins like BCL2 in tumorigenesis highlighting its pivotal role in cancer development and progression. Understanding c-Myc's involvement in these diseases aids in the development of targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed : 24940000, PubMed : 25956029). Activates the transcription of growth-related genes (PubMed : 24940000, PubMed : 25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed : 24940000, PubMed : 25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed : 20010808).
See full target information MYC
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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

British journal of haematology 204:1307-1324 PubMed38462771

2024

Identification of COQ2 as a regulator of proliferation and lipid peroxidation through genome-scale CRISPR-Cas9 screening in myeloma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Li,Chang-Lin Zhang,Di-Sheng Zhou,Sze-Hoi Chan,Xue-Qi Liu,Shu-Na Chen,Zi-Yi Yang,Fei-Er Ju,Xiao-Yan Sang,Zi-Xuan Liu,Qiao-Xia Zhang,Yu-Ming Pan,Si-Si Deng,Xiao-Mei Wang,Li Zhong,Xing-Ding Zhang,Xin Du

British journal of haematology 202:550-565 PubMed37226519

2023

MYC-induced cytidine metabolism regulates survival and drug resistance via cGas-STING pathway in mantle cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Hua Liang,Yi-Min Ren,Kai-Xin Du,Rui Gao,Zi-Wen Duan,Jing-Ran Guo,Tong-Yao Xing,Wei-Ting Wang,Li Wang,Yan Wang,Rong Wang,Jian-Yong Li,Wei Xu

Disease markers 2022:9087190 PubMed35450028

2022

Deubiquitination of TNKS1 Regulates Wnt/-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Tang,Hai Luo,Shenhao Xie,Chengbing Pan,Jun Fu

Oncology reports : PubMed33432363

2021

lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR‑18a‑5p/SOX6 signaling axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhao,Qing Zhang,Hongtao Liu,Ning Wang,Xiaosan Zhang,Shujun Yang

Frontiers in pharmacology 11:541 PubMed32425787

2020

The Hypoglycemic and Renal Protection Properties of Crocin Oxidative Stress-Regulated NF-κB Signaling in db/db Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ye Qiu,Xue Jiang,Danping Liu,Zichun Deng,Weiwei Hu,Zhiping Li,Yuxin Li

Epigenetics 14:1125-1140 PubMed31216925

2019

EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia.

Applications

Unspecified application

Species

Unspecified reactive species

Subazini Thankaswamy Kosalai,Mohammad Hamdy Abdelrazak Morsy,Nikos Papakonstantinou,Larry Mansouri,Niki Stavroyianni,Chandrasekhar Kanduri,Kostas Stamatopoulos,Richard Rosenquist,Meena Kanduri

Molecular cell 74:651-663.e8 PubMed30954402

2019

DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse.

Applications

Unspecified application

Species

Unspecified reactive species

Doria Filipponi,Alexander Emelyanov,Julius Muller,Clement Molina,Jennifer Nichols,Dmitry V Bulavin

Journal of the American Heart Association 8:e009871 PubMed30563421

2018

New Molecular Mechanism Underlying Myc-Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium.

Applications

Unspecified application

Species

Unspecified reactive species

Feifei Guan,Xinlan Yang,Jing Li,Wei Dong,Xu Zhang,Ning Liu,Shan Gao,Jizheng Wang,Lianfeng Zhang,Dan Lu

Oncogene 36:5852-5860 PubMed28628118

2017

OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.

Applications

IP

Species

Unspecified reactive species

A A Ivanov,V Gonzalez-Pecchi,L F Khuri,Q Niu,Y Wang,Y Xu,Y Bai,X Mo,E V Prochownik,M A Johns,Y Du,F R Khuri,H Fu

Methods in molecular biology (Clifton, N.J.) 1012:117-33 PubMed24006062

2013

Chromatin immunoprecipitation assays for Myc and N-Myc.

Applications

Unspecified application

Species

Unspecified reactive species

Bonnie L Barrilleaux,Rebecca Cotterman,Paul S Knoepfler
View all publications
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