AB65842

Anti-C Reactive Protein antibody - Aminoterminal end

Name: Anti-C Reactive Protein antibody - Aminoterminal end (ab65842) | Abcam
Brand: Abcam Limited
SKU: AB65842
Price: 545 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(11 Publications)

Rabbit Polyclonal C Reactive Protein antibody. Suitable for WB and reacts with Rat samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human CRP.

View Alternative Names

PTX1, CRP, C-reactive protein

1 Images

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Western blot - Anti-C Reactive Protein antibody - Aminoterminal end (AB65842)

All lanes:

Western blot - Anti-C Reactive Protein antibody - Aminoterminal end (ab65842) at 2 µg/mL

All lanes:

rat liver tissue lysate at 30 µg

Predicted band size: 25 kDa

Observed band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Synthetic Peptide within Human CRP. The exact immunogen used to generate this antibody is proprietary information.

P02741

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C-reactive protein (CRP) also known as CRP protein is an acute-phase protein with a molecular mass of approximately 25 kDa. It is primarily synthesized in the liver in response to cytokines. This protein appears in the blood where it binds to phosphocholine expressed on the surface of dead or dying cells. CRP is often used as a biomarker for inflammation in the body and its levels in human and canine (anti CRP used) blood samples are measured using assays like the CRP ELISA test or CRP ELISA kit.

Biological function summary

CRP plays a significant role in the innate immune system by recognizing foreign pathogens and damaged cells. It does not form part of a larger complex but itself can bind to specific ligands initiating the complement cascade. This activation enhances phagocytosis by macrophages contributing to the clearance of necrotic and apoptotic cells. The CRP protein therefore acts as a fast responder in the presence of inflammation making it a useful indicator for monitoring inflammatory diseases.

Pathways

CRP operates predominantly within the acute-phase response pathway. Its production is upregulated by cytokines such as IL-6 which connects it to inflammation-signaling pathways. CRP also interacts with the complement system bridging innate and adaptive immunity. Besides CRP could indirectly influence pathways involving other inflammatory proteins like serum amyloid A and haptoglobin creating a network of responses important for managing inflammation.

Elevated CRP levels are commonly associated with cardiovascular diseases and rheumatoid arthritis. In cardiovascular diseases CRP acts as a marker for atherosclerosis where the protein levels correlate with disease severity. It connects with other proteins involved in inflammatory processes such as fibrinogen to contribute to disease pathology. In rheumatoid arthritis CRP provides insights into disease activity helping in the assessment of treatment responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Displays several functions associated with host defense : it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

See full target information CRP

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Veterinary sciences 12: PubMed40284805

2025

Effects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically Induced Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica Silva,Tiago Azevedo,Inês Aires,Catarina Medeiros,Maria J Neuparth,Fernanda Seixas,Rita Ferreira,Ana I Faustino-Rocha,Paula A Oliveira,José Alberto Duarte

Antioxidants (Basel, Switzerland) 12: PubMed37237932

2023

The Impact of Resveratrol-Enriched Bread on Cardiac Remodeling in a Preclinical Model of Diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Andreia F R Silva,Rita Silva-Reis,Rita Ferreira,Paula A Oliveira,Ana I Faustino-Rocha,Maria de Lurdes Pinto,Manuel A Coimbra,Artur M S Silva,Susana M Cardoso

International journal of molecular sciences 24: PubMed37047807

2023

The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Saadia Zahid,Alcir L Dafre,Antonio Currais,Jingting Yu,David Schubert,Pamela Maher

Biomedicines 10: PubMed35203618

2022

An Integrative Approach to Characterize the Early Phases of Dimethylhydrazine-Induced Colorectal Carcinogenesis in the Rat.

Applications

Unspecified application

Species

Unspecified reactive species

Rita Silva-Reis,Catarina Castro-Ribeiro,Mariana Gonçalves,Tiago Ferreira,Maria João Pires,Carlos E Iglesias-Aguirre,Adrián Cortés-Martín,María V Selma,Juan Carlos Espín,Elisabete Nascimento-Gonçalves,Alexandra Moreira-Pais,Maria J Neuparth,Francisco Peixoto,Eduardo Rosa,Adelina Gama,Rita Ferreira,Paula A Oliveira,Ana I Faustino-Rocha

American journal of hypertension 33:119-123 PubMed31560738

2019

Regular Exercise Participation Contributes to Better Proteostasis, Inflammatory Profile, and Vasoactive Profile in Patients With Hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Manuel Teixeira,Marisol Gouveia,Ana Duarte,Miriam Ferreira,Maria I Simões,Maria Conceição,Gladys Silva,Sandra Magalhães,Rita Ferreira,Alexandra Nunes,Sandra I Vieira,Fernando Ribeiro

Archives of gynecology and obstetrics 300:941-955 PubMed31435776

2019

Overall systematic approach to sepsis damages on urogenital tissues: protective power of lacosamide.

Applications

Unspecified application

Species

Unspecified reactive species

Ilker Gunyeli,Mustafa Saygin,Ozlem Ozmen

Aging 11:5445-5462 PubMed31377747

2019

Impact of C-reactive protein on osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Laura A Henze,Trang T D Luong,Beate Boehme,Jaber Masyout,Markus P Schneider,Sebastian Brachs,Florian Lang,Burkert Pieske,Andreas Pasch,Kai-Uwe Eckardt,Jakob Voelkl,Ioana Alesutan

Inflammation 42:1913-1924 PubMed31267274

2019

The Impact of Prophylactic Lacosamide on LPS-Induced Neuroinflammation in Aged Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Mehtap Savran,O Ozmen,Y Erzurumlu,H B Savas,S Asci,M Kaynak

Journal of cellular physiology 234:13481-13492 PubMed30633345

2019

Fibrinopeptide A induces C-reactive protein expression through the ROS-ERK1/2/p38-NF-κB signal pathway in the human umbilical vascular endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Zhao,Shou-Zhu Xu,Juntian Liu

Nature communications 9:5116 PubMed30504805

2018

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Minoru Inoue,Ryota Nakashima,Masahiro Enomoto,Yuhki Koike,Xiao Zhao,Kenneth Yip,Shao Hui Huang,John N Waldron,Mitsuhiko Ikura,Fei-Fei Liu,Scott V Bratman

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C Reactive Protein antibody - Aminoterminal end

Western blot - Anti-C Reactive Protein antibody - Aminoterminal end (AB65842)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Product promise