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AB136176

Anti-C Reactive Protein antibody [C2]

5

(1 Review)

|

(4 Publications)

Mouse Monoclonal C Reactive Protein antibody. Suitable for ELISA, sELISA, IHC-P, cELISA and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CRP.

View Alternative Names

PTX1, CRP, C-reactive protein

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C2

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

cELISA, ELISA, sELISA, IHC-P

applications

Immunogen

Native Full Length Protein corresponding to Human CRP.

P02741

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "cELISA" : {"fullname" : "Competitive ELISA", "shortname":"cELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>Recommended pairs for sandwich immunoassay(capture - detection): C2 - C6.</p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "cELISA-species-checked": "guaranteed", "cELISA-species-dilution-info": "", "cELISA-species-notes": "<p></p>" } } }
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Product details

This product was changed from ascites to tissue culture supernatant on 17th October 2017 and product received after this date will be from tissue culture supernatant.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C-reactive protein (CRP) also known as CRP protein is an acute-phase protein with a molecular mass of approximately 25 kDa. It is primarily synthesized in the liver in response to cytokines. This protein appears in the blood where it binds to phosphocholine expressed on the surface of dead or dying cells. CRP is often used as a biomarker for inflammation in the body and its levels in human and canine (anti CRP used) blood samples are measured using assays like the CRP ELISA test or CRP ELISA kit.
Biological function summary

CRP plays a significant role in the innate immune system by recognizing foreign pathogens and damaged cells. It does not form part of a larger complex but itself can bind to specific ligands initiating the complement cascade. This activation enhances phagocytosis by macrophages contributing to the clearance of necrotic and apoptotic cells. The CRP protein therefore acts as a fast responder in the presence of inflammation making it a useful indicator for monitoring inflammatory diseases.

Pathways

CRP operates predominantly within the acute-phase response pathway. Its production is upregulated by cytokines such as IL-6 which connects it to inflammation-signaling pathways. CRP also interacts with the complement system bridging innate and adaptive immunity. Besides CRP could indirectly influence pathways involving other inflammatory proteins like serum amyloid A and haptoglobin creating a network of responses important for managing inflammation.

Elevated CRP levels are commonly associated with cardiovascular diseases and rheumatoid arthritis. In cardiovascular diseases CRP acts as a marker for atherosclerosis where the protein levels correlate with disease severity. It connects with other proteins involved in inflammatory processes such as fibrinogen to contribute to disease pathology. In rheumatoid arthritis CRP provides insights into disease activity helping in the assessment of treatment responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Displays several functions associated with host defense : it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
See full target information CRP
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:108835 PubMed38384849

2024

Airway inflammation accelerates pulmonary exacerbations in cystic fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Theodore G Liou,Natalia Argel,Fadi Asfour,Perry S Brown,Barbara A Chatfield,David R Cox,Cori L Daines,Dixie Durham,Jessica A Francis,Barbara Glover,My Helms,Theresa Heynekamp,John R Hoidal,Judy L Jensen,Christiana Kartsonaki,Ruth Keogh,Carol M Kopecky,Noah Lechtzin,Yanping Li,Jerimiah Lysinger,Osmara Molina,Craig Nakamura,Kristyn A Packer,Robert Paine,Katie R Poch,Alexandra L Quittner,Peggy Radford,Abby J Redway,Scott D Sagel,Rhonda D Szczesniak,Shawna Sprandel,Jennifer L Taylor-Cousar,Jane B Vroom,Ryan Yoshikawa,John P Clancy,J Stuart Elborn,Kenneth N Olivier,Frederick R Adler

Talanta 240:123157 PubMed34968809

2021

Mitigating hook effect in one-step quantitative sandwich lateral flow assay by timed conjugate release.

Applications

Unspecified application

Species

Unspecified reactive species

Guozhen He,Tao Dong,Zhaochu Yang,Zhuangde Jiang

Evidence-based complementary and alternative medicine : eCAM 2019:4674190 PubMed31379962

2019

Ameliorates Rheumatic Heart Disease by Affecting Relative Percentages of CD4CD25FoxP3 Treg and CD4IL17 T Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tiechao Jiang,Qini Zhao,Hongyan Sun,Lirong Zhang,Shanshan Song,Hongli Chi,Hui Zhou

Talanta 199:164-169 PubMed30952241

2019

Metal-enhanced chemiluminescence detection of C-reaction protein based on silver nanoparticle hybrid probes.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Zong,Duoduo Zhang,Fan Jiang,Hua Yang,Shijia Liu,Ping Li
View all publications
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Product promise

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