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AB186433

Anti-C10orf63 antibody [EPR14013]

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(1 Publication)

Rabbit Recombinant Monoclonal C10orf63 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication.

View Alternative Names

C10orf63, ENKUR, Enkurin

2 Images
Western blot - Anti-C10orf63 antibody [EPR14013] (AB186433)
  • WB

Supplier Data

Western blot - Anti-C10orf63 antibody [EPR14013] (AB186433)

All lanes:

Western blot - Anti-C10orf63 antibody [EPR14013] (ab186433) at 1/10000 dilution

All lanes:

Human testis lysate at 10 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 29 kDa

false

Western blot - Anti-C10orf63 antibody [EPR14013] (AB186433)
  • WB

Supplier Data

Western blot - Anti-C10orf63 antibody [EPR14013] (AB186433)

All lanes:

Western blot - Anti-C10orf63 antibody [EPR14013] (ab186433) at 1/1000 dilution

All lanes:

Mouse testis lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 29 kDa

false

  • Carrier free

    Anti-C10orf63 antibody [EPR14013] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14013

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C10orf63 also known as TMEM119 is a protein that plays a critical role in cellular processes. It has a molecular weight of approximately 54 kDa and is predominantly expressed in microglial cells within the central nervous system. TMEM119 localizes to the plasma membrane contributing to the regulation of specific signaling pathways.
Biological function summary

TMEM119 serves to regulate immune responses in the brain participating as part of a larger complex involving other membrane proteins. It is integral in maintaining microglial identity and function. TMEM119 influences processes such as cell activation migration and phagocytosis. By doing so it contributes to the homeostasis and defense mechanisms in the neural environment.

Pathways

TMEM119 is involved in the TLR4 signaling pathway which is essential for the innate immune responses. It interacts with proteins such as MyD88 which transduces downstream inflammatory signaling cascades. TMEM119's role in this pathway ensures precise control over inflammatory responses and cellular activation which are critically important in the brain's microenvironment.

TMEM119 has a notable connection to neuroinflammation and neurodegenerative diseases particularly Alzheimer's disease and multiple sclerosis. In Alzheimer's disease TMEM119 interaction with proteins like TREM2 suggests a role in modulating inflammatory responses and amyloid-beta phagocytosis. Similarly in multiple sclerosis altered TMEM119 expression can influence microglial activity and contribute to disease progression revealing its importance in pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed : 36191189).
See full target information ENKUR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biology of reproduction 99:789-797 PubMed29733335

2018

The flagellar protein Enkurin is required for mouse sperm motility and for transport through the female reproductive tract.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa K Jungnickel,Keith A Sutton,Mark A Baker,Michael G Cohen,Michael J Sanderson,Harvey M Florman
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com