Mouse Polyclonal C10orf88 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PAAT.
IgG
Mouse
Standard buffer
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Chimpanzee | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Chimpanzee | Dilution info - | Notes - |
ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848).
C10orf88, C10orf88, PAAT, ATPase PAAT, Protein associated with ABC transporters, PAAT
Mouse Polyclonal C10orf88 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PAAT.
IgG
Mouse
Standard buffer
Liquid
Polyclonal
Whole antiserum
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
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This supplementary information is collated from multiple sources and compiled automatically.
C10orf88 also known as CFAP47 is a protein with a molecular weight of approximately 57 kDa. It is expressed in a variety of tissues with notable presence in ciliated cells. This protein is known for its involvement in cellular processes particularly related to structural and functional aspects of cilia which are essential structures for cell motility and sensory functions. The protein lacks extensive characterization; however its localization suggests a role in organellar maintenance or function.
The role of C10orf88 revolves around its association with cilia and potentially flagellar structures. It does not appear to currently form part of an extensively researched protein complex but its activity is integral to the maintenance of proper ciliary function. Through its presumed structural role C10orf88 might influence cilia-related signaling processes that govern cellular responses and communication impacting processes such as cellular motion and signal transduction.
C10orf88 interacts with several cellular signaling pathways related to cilia including the Hedgehog signaling pathway which is essential for developmental processes and tissue patterning. This protein may relate to other ciliary proteins like IFT88 a known player in intracellular transport along cilia affecting the transport and signaling functions that rely on regulated ciliary activities. C10orf88's contributions to pathways highlight the importance of ciliary functionality in broader signaling networks.
C10orf88's dysfunction could contribute to ciliopathies a group of disorders that arise from defects in cilia function and structure such as Bardet-Biedl syndrome. The protein's association with ciliary maintenance suggests a link to these disorders through pathways that involve proteins like BBS1 a component of the BBSome complex essential for ciliogenesis. Understanding of C10orf88 may enhance insights into the molecular mechanisms underlying such genetic disorders and guide therapeutic interventions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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All lanes: Western blot - Anti-C10orf88 antibody (ab169106) at 1/500 dilution
Lane 1: C10orf88-transfected 293T cell lysate at 15 µL
Lane 2: Non-transfected 293T cell lysate at 15 µL
Developed using the ECL technique.
Predicted band size: 49 kDa
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