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Mouse Polyclonal C10orf88 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PAAT.

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Images

Western blot - Anti-C10orf88 antibody (AB169106), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Mouse

Storage buffer

Standard buffer

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human PAAT. Database link Q9H8K7

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Chimpanzee
Predicted

Tested
Tested

Species

Human

Dilution info

1/500 - 1/1000

Notes

-

Predicted
Predicted

Species

Chimpanzee

Dilution info

-

Notes

-

Target data

Function

ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10 (PubMed:25063848). Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival (PubMed:25063848).

Alternative names

Recommended products

Mouse Polyclonal C10orf88 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PAAT.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Full Length Protein corresponding to Human PAAT. Database link Q9H8K7
Purity

Whole antiserum

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

C10orf88 also known as CFAP47 is a protein with a molecular weight of approximately 57 kDa. It is expressed in a variety of tissues with notable presence in ciliated cells. This protein is known for its involvement in cellular processes particularly related to structural and functional aspects of cilia which are essential structures for cell motility and sensory functions. The protein lacks extensive characterization; however its localization suggests a role in organellar maintenance or function.

Biological function summary

The role of C10orf88 revolves around its association with cilia and potentially flagellar structures. It does not appear to currently form part of an extensively researched protein complex but its activity is integral to the maintenance of proper ciliary function. Through its presumed structural role C10orf88 might influence cilia-related signaling processes that govern cellular responses and communication impacting processes such as cellular motion and signal transduction.

Pathways

C10orf88 interacts with several cellular signaling pathways related to cilia including the Hedgehog signaling pathway which is essential for developmental processes and tissue patterning. This protein may relate to other ciliary proteins like IFT88 a known player in intracellular transport along cilia affecting the transport and signaling functions that rely on regulated ciliary activities. C10orf88's contributions to pathways highlight the importance of ciliary functionality in broader signaling networks.

Associated diseases and disorders

C10orf88's dysfunction could contribute to ciliopathies a group of disorders that arise from defects in cilia function and structure such as Bardet-Biedl syndrome. The protein's association with ciliary maintenance suggests a link to these disorders through pathways that involve proteins like BBS1 a component of the BBSome complex essential for ciliogenesis. Understanding of C10orf88 may enhance insights into the molecular mechanisms underlying such genetic disorders and guide therapeutic interventions.

Product promise

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1 product image

  • Western blot - Anti-C10orf88 antibody (ab169106), expandable thumbnail

    Western blot - Anti-C10orf88 antibody (ab169106)

    All lanes: Western blot - Anti-C10orf88 antibody (ab169106) at 1/500 dilution

    Lane 1: C10orf88-transfected 293T cell lysate at 15 µL

    Lane 2: Non-transfected 293T cell lysate at 15 µL

    Developed using the ECL technique.

    Predicted band size: 49 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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