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AB151109

Anti-C10orf99 antibody

5

(1 Review)

|

(3 Publications )

Rabbit Polyclonal C10orf99 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GPR15LG.

View Alternative Names

C10orf99, GPR15L, UNQ1833/PRO3446, GPR15LG, Protein GPR15LG, Antimicrobial peptide with 57 amino acid residues, Colon-derived SUSD2 binding factor, Protein GPR15 ligand, Protein GPR15L, Secreted protein C10orf99, AP-57, Antimicrobial peptide-57, CSBF

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C10orf99 antibody (AB151109)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C10orf99 antibody (AB151109)

Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling C10orf99 with ab151109 at 1/200 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human GPR15LG.

Q6UWK7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C10orf99 also recognized as Apal is a small peptide with a molecular weight of approximately 10 kDa. It exhibits expression in several tissues with high levels in the skin and certain epithelial regions. This protein plays a role in innate immunity where it acts as an antimicrobial peptide. Researchers have identified its presence as particularly relevant in the context of skin infections and inflammation suggesting its potential importance in barrier function.
Biological function summary

The action of C10orf99 involves modulating the immune response by influencing the activation of immune cells. It does not form part of a complex but interacts directly with cell surface receptors to modify cellular responses. This modulation is vital for maintaining immune homeostasis and combating pathogens as well as managing inflammation in tissue-specific contexts.

Pathways

C10orf99 engages in immune-related pathways involving innate immunity and epidermal defense. It interacts with proteins such as the interleukin family contributing to the signaling cascades that govern inflammation and immune cell recruitment. The protein's role within the Toll-like receptor (TLR) pathway highlights its importance in recognizing pathogen-associated molecular patterns aiding in initiating appropriate immune responses.

C10orf99 links to conditions like psoriasis and atopic dermatitis disorders often characterized by dysregulated immune activity and inflammation. In these contexts proteins such as IL-17 have been noted for their roles with C10orf99 potentially influencing or mediating their effects. Its antimicrobial properties and role in modulating inflammation highlight its potential as a therapeutic target in managing these skin-related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed : 28900043, PubMed : 28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed : 25351403). May regulate keratinocyte proliferation (PubMed : 29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed : 35704588).. Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed : 25585381).
See full target information GPR15LG
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International wound journal 21:e14447 PubMed38149752

2023

Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression.

Applications

Unspecified application

Species

Unspecified reactive species

Shola Michelle Richards,Caroline Gubser Keller,Robert Kreutzer,Géraldine Greiner,Svenja Ley,Arno Doelemeyer,Valerie Dubost,Thierry Flandre,Susan Kirkland,Walter Carbone,Rishika Pandya,Judith Knehr,Guglielmo Roma,Sven Schuierer,Laure Bouchez,Klaus Seuwen,Alexandra Aebi,David Westhead,Gabriele Hintzen,Giorgia Jurisic,Imtiaz Hossain,Marilisa Neri,Nenad Manevski,Kamal Kumar Balavenkatraman,Pierre Moulin,Annette Begrich,Barbara Bertschi,Roland Huber,Tewis Bouwmeester,Vickie R Driver,Moritz von Schwabedissen,Dirk Schaefer,Barbara Wettstein,Reto Wettstein,Heinz Ruffner

Frontiers in immunology 13:825032 PubMed35273606

2022

C10orf99/GPR15L Regulates Proinflammatory Response of Keratinocytes and Barrier Formation of the Skin.

Applications

Unspecified application

Species

Unspecified reactive species

Teruki Dainichi,Yuri Nakano,Hiromi Doi,Satoshi Nakamizo,Saeko Nakajima,Reiko Matsumoto,Thomas Farkas,Pui Mun Wong,Vipin Narang,Ricardo Moreno Traspas,Eiryo Kawakami,Emma Guttman-Yassky,Oliver Dreesen,Thomas Litman,Bruno Reversade,Kenji Kabashima

Annals of translational medicine 7:672 PubMed31930073

2020

Decreased expression of EFCC1 and its prognostic value in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Xia,Yunke Zhu,Chuanfen Zhang,Senyi Deng,Yulan Deng,Zhenyu Yang,Jiandong Mei,Lunxu Liu
View all publications
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Product promise

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