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AB135996

Anti-C11orf17 antibody

4

(2 Reviews)

|

(4 Publications)

Rabbit Polyclonal C11orf17 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human AKIP1.

View Alternative Names

BCA3, C11orf17, AKIP1, A-kinase-interacting protein 1, Breast cancer-associated gene 3 protein, PKA-interacting protein, Proline-rich protein BCA3

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human AKIP1. The exact immunogen used to generate this antibody is proprietary information.

Q9NQ31

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C11orf17 also known as Chromosome 11 Open Reading Frame 17 is a protein with a molecular mass of approximately 52 kDa. This protein is expressed in various tissues but it shows higher expression levels in the brain and testis. The specific mechanistic role of C11orf17 is still under investigation but it has been linked to cellular regulation processes potentially through interactions with other proteins.
Biological function summary

C11orf17 seems to play a role in cellular differentiation and development. It is not known to be part of any multi-protein complexes definitively but it engages in interactions with various cellular components to influence cell cycle progression. Studies suggest it might have regulatory impacts on gene expression affecting transcriptional activities in the cells where it is expressed.

Pathways

C11orf17 is implicated in the Wnt signaling pathway a critical pathway for controlling cell fate decisions. Through this pathway it interacts with key proteins such as beta-catenin and possibly influences downstream signaling events responsible for cell proliferation. Additionally it relates to the MAPK pathway another signal transduction pathway that affects cellular responses to growth signals.

C11orf17 has been associated with cancer particularly in terms of its expression levels correlating with tumor progression. Changes in C11orf17 expression might influence cancer pathways through its interaction with beta-catenin. This protein is also related to neurodevelopmental disorders possibly impacting neurological pathways via its expression in the brain and connection to proteins involved in cognitive processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
See full target information AKIP1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 24:558 PubMed35978938

2022

A-kinase interacting protein 1 regulates the cell proliferation, invasion, migration and angiogenesis of clear cell renal cell carcinoma cells and affects the ERK/c-Myc signaling pathway by binding to Rac1.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhang,Haijian Zhang,Zhixing Han,Xudong Wang,Xuyu Li,Pengfei Yuan,Shiqi Ji,Qingjun Liu

Nature communications 13:2256 PubMed35474062

2022

Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Zhu,Ting Gao,Yi Huang,Jing Jin,Di Wang,Leike Zhang,Yanwen Jin,Ping Li,Yong Hu,Yan Wu,Hainan Liu,Qincai Dong,Guangfei Wang,Tong Zheng,Caiwei Song,Yu Bai,Xun Zhang,Yaoning Liu,Weihong Yang,Ke Xu,Gang Zou,Lei Zhao,Ruiyuan Cao,Wu Zhong,Xianzhu Xia,Gengfu Xiao,Xuan Liu,Cheng Cao

PloS one 16:e0252720 PubMed34166397

2021

PKA and AKIP1 interact to mediate cAMP-driven COX-2 expression: A potentially pivotal interaction in preterm and term labour.

Applications

Unspecified application

Species

Unspecified reactive species

Angela Yulia,Natasha Singh,Alice J Varley,Kaiyu Lei,Danijela Markovic,Suren R Sooranna,Mark R Johnson

Frontiers in physiology 8:347 PubMed28620311

2017

Physiological Adaptations to Hypoxic vs. Normoxic Training during Intermittent Living High.

Applications

Unspecified application

Species

Unspecified reactive species

Stefan De Smet,Paul van Herpt,Gommaar D'Hulst,Ruud Van Thienen,Marc Van Leemputte,Peter Hespel
View all publications
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Product promise

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