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AB204420

Anti-C12orf10 antibody

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(2 Publications)

Rabbit Polyclonal C12orf10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MYG1 aa 150-300.

View Alternative Names

C12orf10, MYG1, MYG1 exonuclease

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-C12orf10 antibody (AB204420)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-C12orf10 antibody (AB204420)

Immunofluorescent analysis of PFA/Triton X-100 fixed permeabilized U-251 MG cells labeling C12orf10 with ab204420 at 4 μg/ml (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C12orf10 antibody (AB204420)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C12orf10 antibody (AB204420)

Immunohistochemical analysis of paraffin-embedded Human testis labeing C12orf10 with ab204420 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human MYG1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q9HB07

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C12orf10 also known as MGC54262 is a protein encoded by the C12orf10 gene. The protein has a molecular mass of approximately 20 kDa. It is expressed in several tissues with notable expression in the liver and kidney. Mechanically C12orf10 is involved in intracellular processes although detailed mechanisms are not yet fully understood. The protein localizes within the cytoplasm and may play a role in cellular transport or signaling given its distribution.
Biological function summary

C12orf10 participates in cellular processes that regulate cell growth and differentiation. While not yet fully characterized as part of a larger complex it may interact with other proteins involved in signal transduction. These interactions suggest that C12orf10 could influence cellular communication and the response to extracellular signals. The precise biological implications remain an active area of research aiming to reveal more about how it affects cellular functions.

Pathways

C12orf10 seems to be involved in pathways that pertain to cellular signaling and metabolic regulation. Specifically it likely interacts within the MAPK pathway where it may link to proteins like MEK1/2 which are important in transmitting signals from the cell membrane to the nucleus. This pathway affects cell fate decisions which highlights the role of C12orf10 in cell proliferation and survival. Another potential pathway is the insulin signaling pathway where C12orf10 might influence glucose metabolism highlighting its role in energy balance and cellular homeostasis.

C12orf10 has been associated with metabolic disorders such as diabetes due to its involvement in glucose regulation pathways. The protein's potential interaction with insulin receptor substrate proteins makes it a point of interest in understanding insulin resistance and metabolic syndrome. Additionally there is emerging evidence linking C12orf10 to certain liver diseases including non-alcoholic fatty liver disease (NAFLD). This connection may involve interactions with proteins like AMPK which are important regulators of energy homeostasis and lipid metabolism. Further research is needed to clarify these associations and the therapeutic potential of targeting C12orf10 in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed : 31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).
See full target information MYG1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:4969 PubMed38862489

2024

MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration.

Applications

Unspecified application

Species

Unspecified reactive species

Jianxiong Chen,Shiyu Duan,Yulu Wang,Yuping Ling,Xiaotao Hou,Sijing Zhang,Xunhua Liu,Xiaoli Long,Jiawen Lan,Miao Zhou,Huimeng Xu,Haoxuan Zheng,Jun Zhou

Biochemical and biophysical research communications 509:647-656 PubMed30611568

2019

MiR-141-3p functions as a tumor suppressor through directly targeting ZFR in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weisong Li,Yongmei Cui,Dan Wang,Yuefeng Wang,Liantang Wang
View all publications
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