Rabbit Polyclonal C12orf35 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RESF1 aa 1550 to C-terminus.
View Alternative Names
C12orf35, KIAA1551, RESF1, Retroelement silencing factor 1
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C12orf35 antibody (AB121408)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labeling C12orf35 with ab121408 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- ICC
Unknown
Immunocytochemistry - Anti-C12orf35 antibody (AB121408)
Immunocytochemistry analysis of Human cell line U-251MG shows positivity in nucleoli. Recommended concentration of ab121408 1-4 μg/ml. Cells treated with PFA/Triton X-100.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C12orf35 antibody (AB121408)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labeling C12orf35 with ab121408 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C12orf35 antibody (AB121408)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labeling C12orf35 with ab121408 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C12orf35 antibody (AB121408)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labeling C12orf35 with ab121408 at 1/20 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.
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Biological function summary
C12orf35 has been implicated in transcriptional regulation associating with transcriptional complexes to modulate gene expression. Evidence suggests it participates indirectly in RNA polymerase II-dependent transcription though the exact mechanisms and partners remain to be fully identified. Its broad expression in multiple tissues points to a generalized function across numerous biological processes but further clarification is needed through ongoing studies to pinpoint its precise involvement and interactions.
Pathways
C12orf35 figures in the transcriptional regulation involving RNA polymerase II. This association positions it adjacent to pathways such as signal transduction. It potentially interfaces with proteins involved in these processes like transcriptional activators and repressors further influencing gene expression and cellular responses. Researchers continue to explore the specific pathways seeking to understand better how C12orf35 coordinates within cellular networks and what implications this has for cellular function.
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Publications (1)
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ACS omega 10:30127-30136 PubMed40727815
2025
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