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AB254846

Anti-C13orf31 antibody

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(1 Publication)

Rabbit Polyclonal C13orf31 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LACC1 aa 1-150.

View Alternative Names

C13orf31, FAMIN, LACC1, Purine nucleoside phosphorylase LACC1, Adenosine deaminase LACC1, Fatty acid metabolism-immunity nexus, Guanosine phosphorylase LACC1, Laccase domain-containing protein 1, S-methyl-5'-thioadenosine phosphorylase LACC1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C13orf31 antibody (AB254846)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C13orf31 antibody (AB254846)

Paraffin-embedded human testis tissue stained for C13orf31 using ab254846 at 1/20 dilution in immunohistochemical analysis.

Western blot - Anti-C13orf31 antibody (AB254846)
  • WB

Supplier Data

Western blot - Anti-C13orf31 antibody (AB254846)

All lanes:

Western blot - Anti-C13orf31 antibody (ab254846) at 0.4 µg/mL

Lane 1:

Vector only transfected HEK-293T cell lysate

Lane 2:

C13orf31 overexpressed HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LACC1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q8IV20

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C13orf31 also known as FAM131B is a protein encoded by the gene C13orf31 with a mass of approximately 25 kDa. This protein is expressed in various tissues with a noticeable presence in the brain and testis. Mechanically C13orf31 functions as part of cellular signaling pathways though its exact role remains to be fully understood. Studies have indicated that it may be involved in cellular response mechanisms contributing to maintaining cellular homeostasis.
Biological function summary

The protein plays an essential role in cellular processes that include signal transduction and transcription regulation. C13orf31 participates as part of a larger protein complex that guides these processes within the cell. It interacts with several candidate proteins indicating its potential importance in nucleus-associated functions and possibly affecting transcriptional control.

Pathways

C13orf31 operates within the PI3K-Akt signaling pathway a pathway significant for cell growth and survival. It associates with proteins like AKT1 suggesting that C13orf31 may influence the pathway's outcome especially in cellular growth and survival contexts. Additionally C13orf31 might connect to elements of the MAPK pathway indicating its possible involvement in cellular responses to environmental stress.

Researchers have found links between C13orf31 and certain cancers specifically thyroid cancer. It may work in tandem with RET a proto-oncogene to promote oncogenic activity. Furthermore alterations in C13orf31 expression levels have been observed in several neurological disorders including Alzheimer's disease where it potentially interacts with tau proteins influencing tau pathology and neurodegeneration.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed : 31978345). Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed : 31978345). Also has adenosine deaminase activity (PubMed : 31978345). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed : 31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed : 31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed : 31978345). Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages : associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed : 28593945, PubMed : 31875558). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed : 31875558). Does not show laccase activity (PubMed : 27959965, PubMed : 31978345).
See full target information LACC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 25: PubMed35419615

2022

SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Cai,Zhenhua Sun,Lili Zhang,Hongrui Xu
View all publications
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