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AB91464

Anti-C13orf7 antibody

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(1 Publication)

Rabbit Polyclonal C13orf7 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OBI1 aa 650 to C-terminus.
2 Images
Immunoprecipitation - Anti-C13orf7 antibody (AB91464)
  • IP

Unknown

Immunoprecipitation - Anti-C13orf7 antibody (AB91464)

Sample : whole cell lysate from HeLa cells (1 mg for IP, 20% of IP loaded) .
Antibody : ab91464 at 1 μg/ml for WB and at 10 μg/mg lysate for IP.
Detection : chemiluminescence with exposure times of 10 seconds.

All lanes:

Immunoprecipitation - Anti-C13orf7 antibody (ab91464)

Predicted band size: 81 kDa

false

Western blot - Anti-C13orf7 antibody (AB91464)
  • WB

Unknown

Western blot - Anti-C13orf7 antibody (AB91464)

All lanes:

Western blot - Anti-C13orf7 antibody (ab91464) at 0.04 µg/mL

Lane 1:

HeLa cell lysate at 50 µg

Lane 2:

HeLa cell lysate at 15 µg

Lane 3:

HeLa cell lysate at 5 µg

Lane 4:

293T cell lysate at 50 µg

Predicted band size: 81 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human OBI1 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5W0B1

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Primary Antibodies

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Primary Antibodies

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  • 5
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "5-15 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Opossum": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C13orf7 also known as LOC388268 is a protein with a molecular mass of approximately 26 kDa. This protein is expressed in various human tissues making it a significant target for research in multiple biological contexts. Currently researchers have identified C13orf7 through gene sequencing and have recognized its potential roles in cellular processes although further studies are needed to clarify its mechanical activities. Understanding its expression patterns across tissues can provide insights into its functional significance in different cell types.
Biological function summary

The function of C13orf7 suggests involvement in important cellular functions where it may facilitate interactions that affect cellular homeostasis and response. It's hypothesized to engage as part of multiprotein complexes that influence cellular dynamics although the specific partners and complex memberships remain under investigation. Cellular models lacking C13orf7 display altered phenotypes indicating its importance for maintaining normal cellular processes.

Pathways

Studies connect C13orf7 to pathways like the MAPK signaling pathway which regulates various cellular activities including proliferation and apoptosis. Researchers have noted interactions with kinases like ERK1/2 highlighting a role for C13orf7 in modulating signal transduction and cellular responses. The Wnt signaling pathway also appears to be influenced by C13orf7 particularly affecting β-catenin which further implicates it in cell growth and differentiation processes.

Researchers have explored links between C13orf7 and specific conditions such as cancer and neurodegenerative diseases. Mutations or dysregulation of C13orf7 may correlate with tumorigenesis where it might interact with tumor suppressor genes or oncogenes. In neurodegenerative contexts abnormalities in C13orf7 expression or function may influence pathways involving amyloid precursor proteins contributing to neuronal cell death or dysfunction. Identifying these connections could lead to novel therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed : 31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed : 31160578).
See full target information OBI1

Alternative Names

C13orf7, RNF219, OBI1, ORC ubiquitin ligase 1, RING finger protein 219
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Cellular immunology 353:104129 PubMed32473470

2020

Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly.

Applications

Unspecified application

Species

Unspecified reactive species

Jeffrey R Stinson,Batsukh Dorjbal,Dennis P McDaniel,Liron David,Hao Wu,Andrew L Snow
View all publications
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Product promise

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