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Rabbit Recombinant Monoclonal C15orf24 antibody. Suitable for WB and reacts with Human samples.

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Images

Western blot - Anti-C15orf24 antibody [EPR14097] (AB182568), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested

Tested
Tested

Species
Human
Dilution info
1/10000 - 1/50000
Notes

-

Target data

Function

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).

Alternative names

Recommended products

Rabbit Recombinant Monoclonal C15orf24 antibody. Suitable for WB and reacts with Human samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
EPR14097
Purity
Tissue culture supernatant
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

C15orf24 also known as Chromosome 15 Open Reading Frame 24 is a lesser characterized protein that plays a role in cellular processes. The protein has an approximate mass of 45 kDa. Expression studies show C15orf24 expression in several tissues including heart and liver hinting at its potential roles in important physiological processes. Researchers still work to uncover the full scope of its mechanical function.

Biological function summary

The activities of C15orf24 suggest an involvement in regulating cellular homeostasis. While it has not been fully integrated into any specific protein complex initial findings propose that C15orf24 may have an interaction with proteins involved in cellular signaling. Its expression pattern and interactions imply it may modulate cellular responses to specific stimuli but further studies are needed.

Pathways

C15orf24 has been connected to cellular stress response mechanisms. Proteins related to C15orf24 through these pathways include MAPK signaling components which are integral in stress response and apoptosis pathways. Research indicates that C15orf24 might influence these pathways impacting how cells react to internal and external stress factors.

Associated diseases and disorders

Findings have linked C15orf24 with some aspects of cancer biology and neurodegenerative conditions. Studies suggest that aberrations in C15orf24 expression might relate to the progression of specific cancers potentially through its interaction with proteins such as p53 which regulates the cell cycle. Its potential involvement in neurodegenerative disorders also warrants further investigation as it might affect amyloid-beta metabolism tying it to Alzheimer’s disease research.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Western blot - Anti-C15orf24 antibody [EPR14097] (ab182568), expandable thumbnail

    Western blot - Anti-C15orf24 antibody [EPR14097] (ab182568)

    All lanes: Western blot - Anti-C15orf24 antibody [EPR14097] (ab182568) at 1/10000 dilution

    Lane 1: Human fetal brain tissue lysate at 20 µg

    Lane 2: HeLa cell line lysate at 20 µg

    Secondary

    All lanes: Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated antibody at 1/1000 dilution

    Predicted band size: 26 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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