Rabbit Recombinant Monoclonal C15orf24 antibody. Suitable for WB and reacts with Human samples.
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
WB | |
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Human | Tested |
Species | Dilution info | Notes |
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Species Human | Dilution info 1/10000 - 1/50000 | Notes - |
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
C11orf3, C15orf24, HT022, UNQ905/PRO1926, EMC7, Endoplasmic reticulum membrane protein complex subunit 7, ER membrane protein complex subunit 7
Rabbit Recombinant Monoclonal C15orf24 antibody. Suitable for WB and reacts with Human samples.
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
C15orf24 also known as Chromosome 15 Open Reading Frame 24 is a lesser characterized protein that plays a role in cellular processes. The protein has an approximate mass of 45 kDa. Expression studies show C15orf24 expression in several tissues including heart and liver hinting at its potential roles in important physiological processes. Researchers still work to uncover the full scope of its mechanical function.
The activities of C15orf24 suggest an involvement in regulating cellular homeostasis. While it has not been fully integrated into any specific protein complex initial findings propose that C15orf24 may have an interaction with proteins involved in cellular signaling. Its expression pattern and interactions imply it may modulate cellular responses to specific stimuli but further studies are needed.
C15orf24 has been connected to cellular stress response mechanisms. Proteins related to C15orf24 through these pathways include MAPK signaling components which are integral in stress response and apoptosis pathways. Research indicates that C15orf24 might influence these pathways impacting how cells react to internal and external stress factors.
Findings have linked C15orf24 with some aspects of cancer biology and neurodegenerative conditions. Studies suggest that aberrations in C15orf24 expression might relate to the progression of specific cancers potentially through its interaction with proteins such as p53 which regulates the cell cycle. Its potential involvement in neurodegenerative disorders also warrants further investigation as it might affect amyloid-beta metabolism tying it to Alzheimer’s disease research.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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All lanes: Western blot - Anti-C15orf24 antibody [EPR14097] (ab182568) at 1/10000 dilution
Lane 1: Human fetal brain tissue lysate at 20 µg
Lane 2: HeLa cell line lysate at 20 µg
All lanes: Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated antibody at 1/1000 dilution
Predicted band size: 26 kDa
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