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AB70517

Anti-C17orf57 antibody

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(1 Publication)

Mouse Polyclonal C17orf57 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human EFCAB13.

View Alternative Names

C17orf57, EFCAB13, EF-hand calcium-binding domain-containing protein 13

1 Images
Western blot - Anti-C17orf57 antibody (AB70517)
  • WB

Unknown

Western blot - Anti-C17orf57 antibody (AB70517)

All lanes:

Western blot - Anti-C17orf57 antibody (ab70517) at 1/500 dilution

Lane 1:

C17orf57 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 110 kDa

Observed band size: 65 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human EFCAB13.

Q8IY85

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p>Predicted molecular weight for isoform 2:60 kDa</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C17orf57 also known as GCP2 or GC-rich promoter binding protein 2 is a 17 kDa protein. It has a role in transcriptional regulation processes. This protein is ubiquitously expressed with higher levels in tissues such as the brain and skeletal muscle. It connects to RNA processing and possibly interacts with various components of the transcription machinery.
Biological function summary

C17orf57 contributes to complex processes involved in the regulation of gene expression. It interacts with some components of RNA polymerase II. This interaction suggests that C17orf57 might assist in modulating the synthesis of RNA transcripts a critical step in the flow of genetic information from DNA to protein. This protein may also play a part in nuclear processes related to mRNA stability and localization.

Pathways

C17orf57 plays a significant role in transcription regulation and RNA processing pathways. It works alongside components in the DNA-dependent transcription pathway where interactions with RNA polymerase II are relevant. Additionally C17orf57's presence in an mRNA processing pathway suggests its involvement with proteins like GRWD1 which are associated with gene expression and regulatory events.

C17orf57 has some association with cancer and neurodegenerative diseases. Studies show that its dysregulation may impact cellular processes leading to abnormal cell proliferation and possibly contributing to oncogenesis. C17orf57's interactions with proteins like CTCF may influence chromatin architecture which can impact regulatory pathways involved in these diseases. Alterations in its expression or function might also influence conditions affecting nervous system health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information EFCAB13
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular medicine (Berlin, Germany) 90:895-910 PubMed22367478

2012

Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhou-Yan Bian,Xiang Wei,Shan Deng,Qi-Zhu Tang,Jinghua Feng,Yan Zhang,Chen Liu,Ding-Sheng Jiang,Ling Yan,Lian-Feng Zhang,Manyin Chen,John Fassett,Yingjie Chen,You-Wen He,Qinglin Yang,Peter P Liu,Hongliang Li
View all publications
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