Rabbit Polyclonal C17orf75 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human C17orf75 aa 1-150.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human C17orf75 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HAS0
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
| Mouse | Tested | Tested | Expected |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 0.04000-0.40000 µg/mL | Notes - |
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes Fixation/Permeabilization: PFA/Triton X-100. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Target data
Function
As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865). May have a role in spermatogenesis.
Alternative names
Protein Njmu-R1, C17orf75
Recommended products
Rabbit Polyclonal C17orf75 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Mouse, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human C17orf75 aa 1-150.
Alternative names
Protein Njmu-R1, C17orf75
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human C17orf75 aa 1-150. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HAS0
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The C17orf75 also known as Chromosome 17 Open Reading Frame 75 is a protein of approximately 26 kDa. This protein is mainly expressed in brain tissues and is thought to serve a particular mechanical function within the cell although detailed mechanisms are still under research. Known for being conserved across different species C17orf75's sequence hints at a role that could involve interactions with other cellular components indicating its potential importance in specific physiological processes.
- Biological function summary
C17orf75 is suspected to play a role in neuronal function due to its high expression in brain tissue. It has been suggested that it could be part of a protein complex involved in neuron connectivity or signal transmission. Although specific interactions have not been fully elucidated there is growing evidence that C17orf75 supports synaptic stability and neurotransmission. Insights into this function come from studies that look into its modulation through cellular pathways influencing neuronal health.
- Pathways
Research indicates that C17orf75 may interact with the synaptic vesicle cycle and the neurotransmitter release pathway. This involvement could imply that C17orf75 interacts with proteins like Synaptotagmin and Syntaxin. These functionalities reveal a potential role for C17orf75 in regulating neuronal communications and possibly in the homeostatic balance of neurotransmission. Continued studies are needed to precisely determine the connection of C17orf75 to these pathways and its place in neurophysiological processes.
- Associated diseases and disorders
C17orf75 expression alteration has been related to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In these conditions the protein may interact with neurodegenerative markers like Tau or α-synuclein though more research is needed to confirm these interactions. These associations suggest C17orf75 could serve as a potential biomarker or therapeutic target in the diagnosis or treatment of such neurodegenerative conditions providing insights into disease mechanisms and potential intervention points.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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10 product images
Immunocytochemistry/ Immunofluorescence - Anti-C17orf75 antibody (ab224228)
PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for C17orf75 (green) using ab224228 (4 μg/ml) in ICC/IF.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf75 antibody (ab224228)
Paraffin embedded mouse olfactory bulb tissue stained for C17orf75 with ab224228 (1/200 dilution) in immunohistochemical analysis.
Western blot - Anti-C17orf75 antibody (ab224228)
All lanes: Western blot - Anti-C17orf75 antibody (ab224228) at 1/100 dilution
All lanes: RT4 (human urinary bladder cancer cell line) cell lysate
Predicted band size: 42 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf75 antibody (ab224228)
Paraffin embedded mouse medulla tissue stained for C17orf75 with ab224228 (1/200 dilution) in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf75 antibody (ab224228)
Paraffin embedded mouse denate gyrus tissue stained for C17orf75 with ab224228 (1/200 dilution) in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf75 antibody (ab224228)
Paraffin embedded mouse somatosensory cortex tissue stained for C17orf75 with ab224228 (1/200 dilution) in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf75 antibody (ab224228)
Paraffin embedded mouse piriform cortex tissue stained for C17orf75 with ab224228 (1/200 dilution) in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf75 antibody (ab224228)
Paraffin embedded human stomach tissue stained for C17orf75 with ab224228 (1/200 dilution) in immunohistochemical analysis.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf75 antibody (ab224228)
Paraffin embedded human cerebral cortex tissue stained for C17orf75 with ab224228 (1/200 dilution) in immunohistochemical analysis.
Western blot - Anti-C17orf75 antibody (ab224228)
All lanes: Western blot - Anti-C17orf75 antibody (ab224228) at 1/100 dilution
All lanes: Mouse cerebral cortex tissue lysate
Predicted band size: 42 kDa
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