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AB121246

Anti-C17orf87 antibody

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(1 Publication)

Rabbit Polyclonal C17orf87 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SCIMP aa 1 to C-terminus.

View Alternative Names

C17orf87, UNQ5783/PRO16090, SCIMP, SLP adapter and CSK-interacting membrane protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf87 antibody (AB121246)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C17orf87 antibody (AB121246)

Immunohistochemical staining of paraffin embedded Human tonsil, using 1/150 ab121246, shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction center.

Western blot - Anti-C17orf87 antibody (AB121246)
  • WB

Supplier Data

Western blot - Anti-C17orf87 antibody (AB121246)

All lanes:

Western blot - Anti-C17orf87 antibody (ab121246) at 0.4 µg/mL

Lane 1:

Negative Control (vector only transfected) HEK293T cell lysate

Lane 2:

Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells)

Predicted band size: 17 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SCIMP aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6UWF3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C17orf87 also known as RRG9 and SBNO1 is a protein of approximately 103 kDa. This protein is predominantly expressed in human tissues with a significant presence in the brain and liver indicating its potential relevance to functions in these organs. The protein contains several domains that suggest its involvement in cellular processes possibly through regulatory roles in transcription and signaling pathways.
Biological function summary

C17orf87 functions as a component of larger protein complexes. It plays roles in chromatin modification and gene expression regulation. By interacting with other proteins C17orf87 might influence transcriptional machinery’s access to DNA therefore affecting gene transcription processes. Its expression in the brain proposes a potential role in neural function possibly in processes like neural differentiation and synaptic maintenance.

Pathways

C17orf87 participates in pathways related to transcriptional regulation and signal transduction. Key pathways include chromatin remodeling and neural signaling. Its interaction with proteins such as SNON and HDAC suggests C17orf87's involvement in regulating gene suppression and histone modification affecting how genes get activated or silenced in cellular activities. In neural tissues C17orf87 might cooperate with these pathways to support synaptic function and plasticity.

Alterations in C17orf87 expression have associations with neurological disorders and certain cancers. In neurological disorders its connection to proteins involved in neuronal signaling suggests a role in conditions like schizophrenia or epilepsy. In cancer particularly brain tumors C17orf87's involvement in transcription regulation could influence tumor progression. The protein potentially interlinks with molecules such as histone deacetylases known to play roles in these diseases by modifying chromatin structure and gene expression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed : 21930792). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed : 21930792). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity).
See full target information SCIMP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 10:5026 PubMed31690716

2019

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35.

Applications

Unspecified application

Species

Unspecified reactive species

Pei Y Liu,Andrew E Tee,Giorgio Milazzo,Katherine M Hannan,Jesper Maag,Sujanna Mondal,Bernard Atmadibrata,Nenad Bartonicek,Hui Peng,Nicholas Ho,Chelsea Mayoh,Roberto Ciaccio,Yuting Sun,Michelle J Henderson,Jixuan Gao,Celine Everaert,Amy J Hulme,Matthew Wong,Qing Lan,Belamy B Cheung,Leming Shi,Jenny Y Wang,Thorsten Simon,Matthias Fischer,Xu D Zhang,Glenn M Marshall,Murray D Norris,Michelle Haber,Jo Vandesompele,Jinyan Li,Pieter Mestdagh,Ross D Hannan,Marcel E Dinger,Giovanni Perini,Tao Liu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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