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Rabbit Polyclonal C18orf25 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human C18orf25 aa 1 to C-terminus.

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Images

Western blot - Anti-C18orf25 antibody (AB151616), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C18orf25 antibody (AB151616), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human C18orf25 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q96B23

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

-

Target data

Function

AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling.(Microbial infection) Upon Epstein-Barr virus (EBV) infection, suppresses viral BZLF1 expression and subsequent EBV reactivation by interacting with JUN and inhibiting its transcriptional activitor activity on BZLF1 Z promoter.

Alternative names

Recommended products

Rabbit Polyclonal C18orf25 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human C18orf25 aa 1 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human C18orf25 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q96B23
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

C18orf25 also known as Chromosome 18 Open Reading Frame 25 is a protein with a molecular mass of about 13 kDa. This protein serves mechanical roles associated with intracellular signaling although its precise functions remain under research. Studies show expression of C18orf25 in various tissues with notably higher levels in cardiac and skeletal muscle tissues. The widespread expression suggests a role in multiple cellular processes.

Biological function summary

This protein acts as part of a signaling network influencing cellular responses. While C18orf25 does not form part of a major protein complex it interacts with other cellular components to maintain homeostasis. It may regulate processes linked to muscle function and energy metabolism. Through these interactions it might play a role in maintaining cellular architecture.

Pathways

C18orf25's function plays into metabolic and muscle maintenance pathways. It is linked to the energy production pathway and possibly supports mitochondrial function. C18orf25 interacts indirectly with proteins like AKT as part of the signal transduction cascades which regulate cell growth and survival. These connections suggest that C18orf25 could influence cellular energy balance mechanisms.

Associated diseases and disorders

Research links C18orf25 with metabolic syndrome and cardiomyopathy. This connection comes from its role in energy regulation and muscle tissue function suggesting dysfunction in these areas can contribute to these diseases. The protein's interaction with factors like AMPK implies that imbalances in these pathways could affect disease progression. Understanding C18orf25 could illuminate aspects of these conditions bringing potential for therapeutic targeting.

Product promise

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2 product images

  • Western blot - Anti-C18orf25 antibody (ab151616), expandable thumbnail

    Western blot - Anti-C18orf25 antibody (ab151616)

    10% SDS PAGE

    All lanes: Western blot - Anti-C18orf25 antibody (ab151616) at 1/1000 dilution

    Lane 1: HeLa whole cell lysate at 30 µg

    Lane 2: HepG2 whole cell lysate at 30 µg

    Predicted band size: 43 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C18orf25 antibody (ab151616), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C18orf25 antibody (ab151616)

    Immunohistochemical analysis of paraffin-embedded Human HeLa xenograft tissue labeling C18orf25 with ab151616 at 1/500 dilution.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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