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AB151616

Anti-C18orf25 antibody

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(1 Publication)

Rabbit Polyclonal C18orf25 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARK2N aa 1 to C-terminus.

View Alternative Names

ARKL1, C18orf25, ARK2N, Protein ARK2N, ARKadia-like protein 1, Arkadia (RNF111) N-terminal like PKA signaling regulator protein 2N

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C18orf25 antibody (AB151616)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C18orf25 antibody (AB151616)

Immunohistochemical analysis of paraffin-embedded Human HeLa xenograft tissue labeling C18orf25 with ab151616 at 1/500 dilution.

Western blot - Anti-C18orf25 antibody (AB151616)
  • WB

Unknown

Western blot - Anti-C18orf25 antibody (AB151616)

10% SDS PAGE

All lanes:

Western blot - Anti-C18orf25 antibody (ab151616) at 1/1000 dilution

Lane 1:

HeLa whole cell lysate at 30 µg

Lane 2:

HepG2 whole cell lysate at 30 µg

Predicted band size: 43 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human ARK2N aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96B23

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C18orf25 also known as Chromosome 18 Open Reading Frame 25 is a protein with a molecular mass of about 13 kDa. This protein serves mechanical roles associated with intracellular signaling although its precise functions remain under research. Studies show expression of C18orf25 in various tissues with notably higher levels in cardiac and skeletal muscle tissues. The widespread expression suggests a role in multiple cellular processes.
Biological function summary

This protein acts as part of a signaling network influencing cellular responses. While C18orf25 does not form part of a major protein complex it interacts with other cellular components to maintain homeostasis. It may regulate processes linked to muscle function and energy metabolism. Through these interactions it might play a role in maintaining cellular architecture.

Pathways

C18orf25's function plays into metabolic and muscle maintenance pathways. It is linked to the energy production pathway and possibly supports mitochondrial function. C18orf25 interacts indirectly with proteins like AKT as part of the signal transduction cascades which regulate cell growth and survival. These connections suggest that C18orf25 could influence cellular energy balance mechanisms.

Research links C18orf25 with metabolic syndrome and cardiomyopathy. This connection comes from its role in energy regulation and muscle tissue function suggesting dysfunction in these areas can contribute to these diseases. The protein's interaction with factors like AMPK implies that imbalances in these pathways could affect disease progression. Understanding C18orf25 could illuminate aspects of these conditions bringing potential for therapeutic targeting.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling.. (Microbial infection) Upon Epstein-Barr virus (EBV) infection, suppresses viral BZLF1 expression and subsequent EBV reactivation by interacting with JUN and inhibiting its transcriptional activitor activity on BZLF1 Z promoter.
See full target information ARK2N
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

European journal of pharmacology 910:174448 PubMed34454926

2021

Na-dependent inactivation of vascular Na/Ca exchanger responsible for reduced peripheral blood flow in neuropathic pain model.

Applications

Unspecified application

Species

Unspecified reactive species

Hirotake Ishida,Momoka Yamaguchi,Shin-Ya Saito,Takuma Furukawa,John L Shannonhouse,Yu Shin Kim,Tomohisa Ishikawa
View all publications
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Product promise

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