Anti-C19orf47 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

C19orf47 also known by alternate names such as Chromosome 19 Open Reading Frame 47 is a protein-coding gene located on human chromosome 19. It encodes a protein with a mass of approximately 46 kDa. This protein has localization in the cytoplasm and nucleus showing expression across various tissues but particularly enriched in immune cells. Researchers have suggested roles in cellular processes due to its conserved domains but the exact mechanical functions of C19orf47 remain not fully described.

Biological function summary

C19orf47 plays a role in the regulation of immune response possibly impacting cell signaling and proliferation. It functions as part of a larger protein complex interacting with key cellular machinery to modulate various biological processes. The protein has close associations with other regulatory proteins that influence immune cell dynamics. This suggests that C19orf47 may have broader implications in immune system homeostasis and adaptability.

Pathways

The evolutionarily conserved protein C19orf47 is involved in pathways linked to immune signaling networks. It participates in the regulation of signal transduction pathways such as the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathway critical for immune and inflammatory responses. Additionally C19orf47 interacts with proteins like IκB influencing the pathway's activation and inhibition processes. This indicates its potential role in modulating immune responses and cellular defense mechanisms.

Associated diseases and disorders

Research implicates C19orf47 in conditions related to immune dysregulation such as autoimmune diseases and certain cancers. It has connections to proteins involved in autoimmune diseases highlighting a potential role in disease pathogenesis due to alterations in immune signaling. Investigations continue to explore its association with other proteins like TNF (tumor necrosis factor) in these disorders. Understanding the involvement of C19orf47 in disease can lead to new insights into disease mechanisms and therapeutic targets.