Rabbit Polyclonal C1orf123 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CZIB aa 1-100.
Images
Publications
Filter by
- International journal of molecular sciences 23:2021New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDominique de Seny,Dominique Baiwir,Elettra Bianchi,Gaël Cobraiville,Céline Deroyer,Christophe Poulet,Olivier Malaise,Geneviève Paulissen,Marie-Joëlle Kaiser,Jean-Philippe Hauzeur,Gabriel Mazzucchelli,Philippe Delvenne,Michel MalaisePubMed 35008858
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human CZIB aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NWV4
Reactivity data
Select an application| IHC-P | WB | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/50.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.04000-0.40000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Target data
Alternative names
C1orf123, CZIB, CXXC motif containing zinc binding protein, UPF0587 protein C1orf123
Recommended products
Rabbit Polyclonal C1orf123 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CZIB aa 1-100.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human CZIB aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NWV4
- Concentration
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
C1orf123 also known as Chromosome 1 Open Reading Frame 123 is a protein with a molecular mass of approximately 33 kDa. It is expressed in various tissues including the brain liver and testes indicating its potential role in multiple physiological processes. While the precise mechanical function of C1orf123 remains under investigation researchers suggest it may have roles in cellular signaling or structural functions due to its expression profile.
- Biological function summary
C1orf123 associates with cellular differentiation and development. The protein functions as a part of cellular complexes indicating its involvement in intricate biological interactions. Studies highlight its potential interaction with factors that regulate gene expression which may influence cellular growth and development processes. This suggests that C1orf123's role extends to influencing cellular function and maintenance.
- Pathways
C1orf123 integrates within major cellular processes and networks. It participates in the MAPK signaling pathway important for regulating various cellular activities such as proliferation and apoptosis. C1orf123 is also linked with the PI3K-Akt pathway which plays an important role in controlling cell metabolism and growth. Through these pathways C1orf123 interacts with proteins like RAF1 and AKT1 impacting essential functions that maintain cellular health and homeostasis.
- Associated diseases and disorders
Research has identified connections between C1orf123 and neurodegenerative diseases like Alzheimer's disease. Additionally abnormalities in C1orf123 expression have associations with certain forms of cancer particularly those affecting the liver. The protein's interaction with proteins such as APP in Alzheimer's and TP53 in cancer underlines its importance in the pathology of these conditions. Studies continue to explore its potential as a biomarker or therapeutic target in these diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
Immunocytochemistry/ Immunofluorescence - Anti-C1orf123 antibody (ab122865)
Immunofluorescent staining of Human cell line U-2 OS shows positivity in cytoplasm. Recommended concentration of ab122865 1-4 µg/ml. Cells treated with PFA/Triton X-100.
Western blot - Anti-C1orf123 antibody (ab122865)
Lane 1: Marker [kDa] 250; 130; 95; 72; 55; 36; 28; 17; 10
Lane 2: Negative control (vector only transfected HEK293T lysate)
Lane 3: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells.All lanes: Western blot - Anti-C1orf123 antibody (ab122865)
Predicted band size: 18 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1orf123 antibody (ab122865)
ab122865 at 1/20 dilution staining C1orf123 in paraffin-embedded Human liver tissue by Immunohistochemistry.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com