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AB126543

Anti-C1orf192 antibody

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(1 Publication)

Rabbit Polyclonal C1orf192 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CFAP126 aa 100 to C-terminus.

View Alternative Names

C1orf192, FLTP, CFAP126, Protein Flattop, Cilia- and flagella-associated protein 126

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-C1orf192 antibody (AB126543)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-C1orf192 antibody (AB126543)

Immunofluorescent staining of Human cell line A-431 shows positivity in cytoplasm. Recommended concentration of ab126543 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1orf192 antibody (AB126543)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1orf192 antibody (AB126543)

ab126543, at 1/200 dilution, staining C1orf192 in paraffin-embedded Human stomach tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CFAP126 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5VTH2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C1orf192 also referred to as Chromosome 1 open reading frame 192 has a molecular mass of approximately 34 kDa. It is expressed in multiple tissues throughout the body but shows higher levels in specific regions like the liver and the brain. Mechanically C1orf192 is hypothesized to function as a binding protein possibly interacting with other proteins to facilitate cellular processes. Its specific domains suggest a role in protein-protein interactions although detailed binding partners and the exact nature of its interactions remain under investigation.
Biological function summary

C1orf192 integrates into cellular functions that are essential for maintaining normal cellular homeostasis. It appears to be involved in regulatory activities though the details of its biological role are still studied. C1orf192 does not seem to be a part of large well-characterized complexes which makes it a harder target for straightforward functional dissection. However ongoing research suggests its potential involvement in modulating cellular signal transduction and possibly influencing cell cycle progression.

Pathways

Our understanding of C1orf192 involves its potential participation in signal transduction and cellular response pathways. It may interact with proteins involved in the AKT signaling pathway which is essential for regulating cell survival and proliferation. While direct interactors in the pathway are not comprehensively established C1orf192 might connect to proteins like PI3K or mTOR suggesting a putative role in these pathways. The exact integration of C1orf192 within these networks requires further experimental validation.

C1orf192 has been linked to neurological conditions suggesting its role in brain-specific functional pathways. Observations connect this target to Alzheimer's Disease where its altered expression might impact disease progression. Furthermore its potential interaction with Beta-amyloid precursor proteins and tau proteins highlights the need to explore its contribution to neurodegenerative mechanisms. Continued studies are important to establish precise causative relationships and therapeutic potentials.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (PubMed : 36191189). Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells (By similarity). Regulates basal body docking and cilia formation in multiciliated lung cells (By similarity). Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear (By similarity).
See full target information CFAP126
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2403591 PubMed39498824

2024

An EED/PRC2-H19 Loop Regulates Cerebellar Development.

Applications

Unspecified application

Species

Unspecified reactive species

Pei-Pei Liu,Xiao Han,Xiao Li,Shang-Kun Dai,Ya-Jie Xu,Lin-Fei Jiao,Hong-Zhen Du,Li-Hua Zhao,Rong-Feng Li,Zhao-Qian Teng,Yun-Gui Yang,Chang-Mei Liu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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