Anti-C1q antibody 4.8 is a rabbit monoclonal antibody that is used in C1q IHC. Suitable for Mouse samples.
- Specificity confirmed with C1QA knockout cell line validation
- Recombinant format for unrivaled batch-batch consistency
- Cited in over 60 publications
Images
![Immunohistochemistry (Frozen sections) - Anti-C1q antibody [4.8] (AB182451), expandable thumbnail](https://content.abcam.com/products/images/c1q-antibody-48-ab182451--immunohistochemistry-frozen-sections-img3569.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Frozen sections) - Anti-C1q antibody [4.8] (AB182451)")
Publications
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- PLoS pathogens 19:e10113502023Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGeoffrey T Norris,Joshua M Ames,Steven F Ziegler,Andrew OberstPubMed 37983247
- Alzheimer's research & therapy 15:2012023Neuronal transcriptome, tau and synapse loss in Alzheimer's knock-in mice require prion protein.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAustin Stoner,Li Fu,LaShae Nicholson,Chao Zheng,Takuya Toyonaga,Joshua Spurrier,Will Laird,Zhengxin Cai,Stephen M StrittmatterPubMed 37968719
- Journal of neuroinflammation 20:2612023NeuroD1 administration ameliorated neuroinflammation and boosted neurogenesis in a mouse model of subarachnoid hemorrhage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPing Chen,Xue-Yan Liu,Mou-Hui Lin,Yu-Xi Li,De-Zhi Kang,Zu-Cheng Ye,Qing-Song LinPubMed 37953259
- Cells 12:2023Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKyle J Connolly,Juliette Margaria,Erika Di Biase,Oliver Cooper,Penelope J Hallett,Ole IsacsonPubMed 37947642
- Translational psychiatry 13:3322023Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArpit Kumar Pradhan,Tatjana Neumüller,Claudia Klug,Severin Fuchs,Martin Schlegel,Markus Ballmann,Katharina Johanna Tartler,Antoine Pianos,Maria Sanchez Garcia,Philippe Liere,Michael Schumacher,Matthias Kreuzer,Rainer Rupprecht,Gerhard RammesPubMed 37891168
- Frontiers in molecular biosciences 10:12503352023Primary cilia-mediated regulation of microglial secretion in Alzheimer's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSeungeun Yeo,Jaemyung Jang,Hyun Jin Jung,Hyeyoung Lee,Youngshik ChoePubMed 37942288
- The Journal of experimental medicine 220:2023Maternal diet during early gestation influences postnatal taste activity-dependent pruning by microglia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChengsan Sun,Shuqiu Zheng,Justin S A Perry,Geoffrey T Norris,Mei Cheng,Fanzhen Kong,Rolf Skyberg,Jianhua Cang,Alev Erisir,Jonathan Kipnis,David L HillPubMed 37733279
- Scientific reports 13:151642023Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRia Thomas,Kyle J Connolly,Oeystein R Brekk,Anthony J Hinrich,Michelle L Hastings,Ole Isacson,Penelope J HallettPubMed 37704739
- Nature 620:1071-10792023Platelet factors attenuate inflammation and rescue cognition in ageing.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAdam B Schroer,Patrick B Ventura,Juliana Sucharov,Rhea Misra,M K Kirsten Chui,Gregor Bieri,Alana M Horowitz,Lucas K Smith,Katriel Encabo,Imelda Tenggara,Julien Couthouis,Joshua D Gross,June M Chan,Anthony Luke,Saul A VilledaPubMed 37587343
- Nature neuroscience 26:406-4152023Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSebastiaan De Schepper,Judy Z Ge,Gerard Crowley,Laís S S Ferreira,Dylan Garceau,Christina E Toomey,Dimitra Sokolova,Javier Rueda-Carrasco,Sun-Hye Shin,Jung-Seok Kim,Thomas Childs,Tammaryn Lashley,Jemima J Burden,Michael Sasner,Carlo Sala Frigerio,Steffen Jung,Soyon HongPubMed 36747024
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC-Fr | |
|---|---|
| Mouse | Tested |
IHC-Fr
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1 µg/mL | Notes ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
Associated Products
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1 product for Alternative Version
Target data
Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Alternative names
Complement C1q subcomponent subunit A, C1qa
Recommended products
Anti-C1q antibody 4.8 is a rabbit monoclonal antibody that is used in C1q IHC. Suitable for Mouse samples.
- Specificity confirmed with C1QA knockout cell line validation
- Recombinant format for unrivaled batch-batch consistency
- Cited in over 60 publications
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- 4.8
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-C1q antibody [4.8] (ab182451) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-Fr in mouse samples.
Anti-C1q antibody [4.8] (ab182451) has been cited over 67 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-C1q antibody [4.8] (ab182451) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
The specificity of Anti-C1q antibody [4.8] (ab182451) has been confirmed by testing in knockout samples.
Anti-C1q antibody [4.8] (ab182451) specifically detects C1q (UniProt ID: P02745; Molecular weight: 24kDa) and is sold in 100 µL and 1 mL selling sizes.
This antibody was developed as part of a collaboration between Abcam and the lab of Ben A. Barres at Stanford University:
Alexander H. Stephan et al. , A Dramatic Increase of C1q Protein in the CNS during Normal Aging ,The Journal of Neuroscience.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
![Immunohistochemistry (Frozen sections) - Anti-C1q antibody [4.8] (ab182451), expandable thumbnail](https://content.abcam.com/products/images/c1q-antibody-48-ab182451--immunohistochemistry-frozen-sections-img3569.jpg "Immunohistochemistry (Frozen sections) - Anti-C1q antibody [4.8] (ab182451)")
This image is kindly provided by Dr. Daniel Wilton from Boston Children’s Hospital.Immunohistochemistry (Frozen sections) - Anti-C1q antibody [4.8] (ab182451)
ab182451 (1/500) staining C1q in 15μm coronal brain sections from postnatal day 90 C1qA KO mice and WT litter-mates (Botto et al., 1998) by immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with 4% paraformaldehyde and permeabilized with 0.3% Triton. An Alexa Flour-conjugated Goat anti-Mouse IgG polyclonal (1/500) was used as the secondary antibody. Positive staining on wild type (WT) mouse cerebral cortex, and no staining on knockout (KO) mouse cerebral cortex.
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