Rat Recombinant Monoclonal C1QA antibody. Suitable for ELISA, IHC-FoFr, ICC/IF, IHC-Fr and reacts with Mouse, Human samples. Cited in 18 publications.
Images
![Immunohistochemistry (Frozen sections) - Anti-C1q antibody [7H8] (AB11861), expandable thumbnail](https://content.abcam.com/products/images/c1q-antibody-7h8-ab11861--immunohistochemistry-frozen-sections-img183407.jpg/_jcr_content/renditions/webp-475.webp "Immunohistochemistry (Frozen sections) - Anti-C1q antibody [7H8] (AB11861)")
Publications
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- Stem cell research & therapy 14:2572023Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYiming Wang,Lin Jing,Xiao Lei,Zhen Ma,Bei Li,Yuanyuan Shi,Wuyang Zhang,Yuan Li,Hongzhi Zhou,Kaijin Hu,Yang Xue,Yan JinPubMed 37726853
- Journal of clinical and translational hepatology 11:540-5492023Fas/FasL and Complement Activation are Associated with Chronic Active Epstein-Barr Virus Hepatitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Lin,Miao-Fang Su,Jiao-Long Zheng,Lei Gu,Hai-Cong Wu,Xia Wu,Hai-Yan Lin,Zhi-Xian Wu,Dong-Liang LiPubMed 36969885
- Journal of neuroinflammation 19:1422022Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYeonggwang Hwang,Hyoung-Chun Kim,Eun-Joo ShinPubMed 35690821
- Frontiers in immunology 12:7852872022Complement Inhibition Alleviates Cholestatic Liver Injury Through Mediating Macrophage Infiltration and Function in Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhenya Guo,Junze Chen,Yonglian Zeng,Zefeng Wang,Mei Yao,Stephen Tomlinson,Bin Chen,Guandou Yuan,Songqing HePubMed 35069557
- Science advances 7:eabj34002021Social isolation-related depression accelerates ethanol intake via microglia-derived neuroinflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJin-Seok Lee,Sung-Bae Lee,Dong-Woon Kim,Nara Shin,Seon-Ju Jeong,Chae-Ha Yang,Chang-Gue SonPubMed 34739315
- Cellular and molecular gastroenterology and hepatology 13:289-3072021C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHai-Yun Li,Zhao-Ming Tang,Zhe Wang,Jian-Min Lv,Xiao-Ling Liu,Yu-Lin Liang,Bin Cheng,Ning Gao,Shang-Rong Ji,Yi WuPubMed 34536564
- Scientific reports 9:203572019Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJunya Hata et. al.PubMed 31889151
- Nature communications 10:38902019Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesClaudia P Figueiredo et. al.PubMed 31488835
- Acta neuropathologica 133:785-8072017Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHideyuki Takahashi et. al.PubMed 28070672
- Oncoimmunology 5:e12536532016The non-inflammatory role of C1q during Her2/neu-driven mammary carcinogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSilvio Bandini et. al.PubMed 28123895
Key facts
- Isotype
- IgG1
- Host species
- Rat
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Reactivity data
Select an application| ELISA | IHC-FoFr | ICC/IF | IHC-Fr | WB | IHC-P | |
|---|---|---|---|---|---|---|
| Human | Expected | Expected | Expected | Predicted | Not recommended | Not recommended |
| Mouse | Expected | Expected | Expected | Tested | Not recommended | Not recommended |
| Rat | Not recommended | Not recommended | Not recommended | Not recommended | Not recommended | Not recommended |
ELISA
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human | Dilution info Use at an assay dependent concentration. | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
IHC-FoFr
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human | Dilution info Use at an assay dependent concentration. | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Human | Dilution info Use at an assay dependent concentration. | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
IHC-Fr
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
WB
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
7 products for Alternative Product
Target data
Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Alternative names
Complement C1q subcomponent subunit A, C1QA
Recommended products
Rat Recombinant Monoclonal C1QA antibody. Suitable for ELISA, IHC-FoFr, ICC/IF, IHC-Fr and reacts with Mouse, Human samples. Cited in 18 publications.
Key facts
- Isotype
- IgG1
- Host species
- Rat
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Clone number
- 7H8
- Purification technique
- Affinity purification Protein A
- Specificity
Immunization schedule and immunogen used has been described in the following article: Wasiliu, M et al; Monoclonal antibodies to complement components without the need of their prior purification. I. Antibodies to mouse C1q. Hybridoma 1989, 8 (6): 615.
- Light chain type
- kappa
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was switched from a hybridoma to a recombinant production format on 25th October 2021.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
![Immunohistochemistry (Frozen sections) - Anti-C1q antibody [7H8] (ab11861), expandable thumbnail](https://content.abcam.com/products/images/c1q-antibody-7h8-ab11861--immunohistochemistry-frozen-sections-img183407.jpg "Immunohistochemistry (Frozen sections) - Anti-C1q antibody [7H8] (ab11861)")
Immunohistochemistry (Frozen sections) - Anti-C1q antibody [7H8] (ab11861)
Positive staining on P90 Wild-type mouse, and no staining on P90 C1qa Knockout Mouse . Primary antibody was applied at a dilution of 1/500 and anti-VGLUT1 antibody. Secondary antibodies including goat anti rabbit IgG (H+L) highly cross-adsorbed Alexa Fluor 594 and goat anti guinea pig IgG (H+L) highly cross-adsorbed Alexa Fluor 488 were also employed at a dilution of 1/500.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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