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AB268120

Anti-C1q antibody [C1QA/2956]

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(7 Publications)

Anti-C1q antibody [C1QA/2956] (ab268120) is a mouse monoclonal antibody detecting C1q in IHC-P. Suitable for Human.

View Alternative Names

Complement C1q subcomponent subunit A, C1QA

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1q antibody [C1QA/2956] (AB268120)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1q antibody [C1QA/2956] (AB268120)

Formalin-fixed, paraffin-embedded human liver tissue stained for C1q using ab268120 at 2 μg/ml in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1q antibody [C1QA/2956] (AB268120)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1q antibody [C1QA/2956] (AB268120)

Formalin-fixed, paraffin-embedded human kidney tissue stained for C1q using ab268120 at 2 μg/ml in immunohistochemical analysis.

Protein Array - Anti-C1q antibody [C1QA/2956] (AB268120)
  • Protein Array

Unknown

Protein Array - Anti-C1q antibody [C1QA/2956] (AB268120)

Protein Array containing more than 19,000 full-length human proteins using ab268120.

Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C1QA/2956

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

Protein Array, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human C1QA aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P02745

Reactivity data

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Product details

What is this antibody validated in?
Anti-C1q antibody [C1QA/2956] (ab268120) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.

Other related products
We have a range of other formats of antibody clone [C1QA/2956] also available for your convenience: ab268120, Carrier free - ab268243

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from bioreactor concentrate.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed : 12847249, PubMed : 19006321, PubMed : 24626930, PubMed : 29449492, PubMed : 3258649, PubMed : 34155115, PubMed : 6249812, PubMed : 6776418). The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens : C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain (PubMed : 12847249, PubMed : 19006321, PubMed : 24626930, PubMed : 29449492, PubMed : 3258649, PubMed : 6776418). Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system (PubMed : 29449492). The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM (PubMed : 19706439, PubMed : 24626930, PubMed : 29449492). The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system (PubMed : 18250442).
See full target information C1QA

Publications (7)

Recent publications for all applications. Explore the full list and refine your search

BMC nephrology 25:387 PubMed39478440

2024

The prognostic role of activation of the complement pathways in the progression of advanced IgA nephropathy to end-stage renal disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Wang,Shimin Jiang,Dingxin Di,Guming Zou,Hongmei Gao,Shunlai Shang,Wenge Li

JCI insight 8: PubMed36821371

2023

EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids.

Applications

Unspecified application

Species

Unspecified reactive species

Charlie J Childs,Emily M Holloway,Caden W Sweet,Yu-Hwai Tsai,Angeline Wu,Abigail Vallie,Madeline K Eiken,Meghan M Capeling,Rachel K Zwick,Brisa Palikuqi,Coralie Trentesaux,Joshua H Wu,Oscar Pellón-Cardenas,Charles J Zhang,Ian Glass,Claudia Loebel,Qianhui Yu,J Gray Camp,Jonathan Z Sexton,Ophir D Klein,Michael P Verzi,Jason R Spence

Frontiers in immunology 13:890094 PubMed35686134

2022

Sex-Differences and Associations Between Complement Activation and Synovial Vascularization in Patients with Late-Stage Knee Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Emily U Sodhi,Holly T Philpott,McKenzie M Carter,Trevor B Birmingham,C Thomas Appleton

Frontiers in medicine 9:845679 PubMed35479942

2022

Activation of Complement Pathways in Kidney Tissue May Mediate Tubulointerstitial Injury in Diabetic Nephropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Shimin Jiang,Yuanyuan Jiao,Guming Zou,Hongmei Gao,Li Zhuo,Wenge Li

Journal of diabetes investigation 13:839-849 PubMed34932275

2022

Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Jiao,Shimin Jiang,Ying Wang,Tianyu Yu,Guming Zou,Li Zhuo,Wenge Li

Cell 184:2988-3005.e16 PubMed34019793

2021

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandar Obradovic,Nivedita Chowdhury,Scott M Haake,Casey Ager,Vinson Wang,Lukas Vlahos,Xinzheng V Guo,David H Aggen,W Kimryn Rathmell,Eric Jonasch,Joyce E Johnson,Marc Roth,Kathryn E Beckermann,Brian I Rini,James McKiernan,Andrea Califano,Charles G Drake

PloS one 16:e0244743 PubMed33411796

2021

Transcriptional profiling of pediatric cholestatic livers identifies three distinct macrophage populations.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah A Taylor,Shang-Yang Chen,Gaurav Gadhvi,Liang Feng,Kyle D Gromer,Hiam Abdala-Valencia,Kiwon Nam,Salina T Dominguez,Anna B Montgomery,Paul A Reyfman,Lorena Ostilla,Joshua B Wechsler,Carla M Cuda,Richard M Green,Harris Perlman,Deborah R Winter
View all publications

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