AB71940

Anti-C1q antibody [JL-1]

Name: Anti-C1q antibody [JL-1] (ab71940) | Abcam
Brand: Abcam Limited
SKU: AB71940
Price: 410 USD
Availability: InStock
Rating: 4 (12 reviews)

(12 Reviews)

(49 Publications)

Anti-C1q antibody [JL-1] (ab71940) is a mouse monoclonal antibody detecting C1q in ELISA, Dot Blot. Suitable for Human, Mouse.

- Over 30 publications
- Trusted since 2010

View Alternative Names

Complement C1q subcomponent subunit A, C1QA

2 Images

Supplier Data

Dot Blot - Anti-C1q antibody [JL-1] (AB71940)

Dot blot with ab71940 with mouse serum and human plasma with different amounts of C1q.

ELISA - Anti-C1q antibody [JL-1] (AB71940)

ELISA

Supplier Data

ELISA - Anti-C1q antibody [JL-1] (AB71940)

ab71940 was used as a detection antibody in different concentrations.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

JL-1

Isotype

IgG2b

Carrier free

Reacts with

Mouse, Human

Applications

Dot, ELISA

applications

Immunogen

Native Full Length Protein corresponding to Mouse C1qa.

P98086

Epitope

The monoclonal antibody JL-1is reactive with the collagen-like region (CLR).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "Dot-species-checked": "testedAndGuaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "Dot-species-checked": "testedAndGuaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "" }, "Rat": { "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "Dot-species-checked": "predicted", "Dot-species-dilution-info": "", "Dot-species-notes": "" }, "Recombinant full length protein - Mouse": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "Dot-species-checked": "notRecommended", "Dot-species-dilution-info": "", "Dot-species-notes": "" } } }

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Product details

What is this antibody validated in?
Anti-C1q antibody [JL-1] (ab71940) is a mouse monoclonal antibody and is validated for use in ELISA, Dot Blot in Human, Mouse samples.

Trusted by the scientific community
Anti-C1q [JL-1] (ab71940) was first used in a scientific publication in 2010 and has been cited over 30 times in peer-reviewed journals.

Reviewed by scientists
Anti-C1q [JL-1] (ab71940) has over 10 independent reviews from customers.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

0.2µm filtered.

Storage buffer

Constituents: PBS, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

See full target information C1QA

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Publications (49)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 23:580 PubMed40847354

2025

Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation.

Applications

Unspecified application

Species

Unspecified reactive species

Shiyi Xu,Nana Bie,Xinzhuang Su,Xiaojuan Zhang,Shiyu Li,Haojie Liu,Tuying Yong,Qing Chen,Xiangliang Yang,Lu Gan

Theranostics 15:6628-6650 PubMed40585999

2025

Gut microbiota depletion accelerates hematoma resolution and neurological recovery after intracerebral hemorrhage via p-coumaric acid-promoted Treg differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yonghe Zheng,Yin Li,Xuchao He,Yuhan Zhu,Shiyu Xu,Yirong Feng,Yirui Kuang,Huaijun Chen,Linfeng Fan,Huaping Huang,Libin Hu,Xian Yu,Jianan Wu,Lingji Jin,Junwen Hu,Xiongjie Fu,Hanhai Zeng,Shenglong Cao,Lin Wang

Frontiers in immunology 15:1426975 PubMed39399501

2024

Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah A DeVries,Christina Dimovasili,Maria Medalla,Tara L Moore,Douglas L Rosene

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2401634 PubMed38888507

2024

T Cell-Derived Apoptotic Extracellular Vesicles Hydrolyze cGAMP to Alleviate Radiation Enteritis via Surface Enzyme ENPP1.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Zhou,Lili Bao,Shengkai Gong,Geng Dou,Zihan Li,Zhengyan Wang,Lu Yu,Feng Ding,Huan Liu,Xiayun Li,Siying Liu,Xiaoshan Yang,Shiyu Liu

GeroScience 46:2503-2519 PubMed37989825

2023

Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah A DeVries,Bryce Conner,Christina Dimovasili,Tara L Moore,Maria Medalla,Farzad Mortazavi,Douglas L Rosene

Nature medicine 29:2866-2884 PubMed37814059

2023

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel K Wilton,Kevin Mastro,Molly D Heller,Frederick W Gergits,Carly Rose Willing,Jaclyn B Fahey,Arnaud Frouin,Anthony Daggett,Xiaofeng Gu,Yejin A Kim,Richard L M Faull,Suman Jayadev,Ted Yednock,X William Yang,Beth Stevens

Journal of neuroinflammation 20:201 PubMed37660145

2023

Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxin Zhou,Hrishti Bhatt,Chromewell A Mojica,Hongqi Xin,Monica A Pessina,Douglas L Rosene,Tara L Moore,Maria Medalla

Investigative ophthalmology & visual science 64:3 PubMed36729444

2023

Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates.

Applications

Unspecified application

Species

Unspecified reactive species

Anita Grover,Sethu Sankaranarayanan,Vidhu Mathur,Poojan Suri,Haiyan Qiu,Yaisa Andrews-Zwilling,Kirsten Mease,Lori K Taylor,Ellen Cahir-McFarland,Sanjay Keswani,Ted Yednock

Molecular neurobiology 60:1527-1536 PubMed36515857

2022

Blockade of Type 2A Protein Phosphatase Signaling Attenuates Complement C1q-Mediated Microglial Phagocytosis of Glutamatergic Synapses Induced by Amyloid Fibrils.

Applications

Unspecified application

Species

Unspecified reactive species

Jiang Wu,Jijun Xu,Mohamed Naguib,Bihua Bie

Frontiers in immunology 13:919444 PubMed36189326

2022

Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Yonghe Zheng,Linfeng Fan,Siqi Xia,Qiguo Yang,Zhihua Zhang,Huaijun Chen,Hanhai Zeng,Xiongjie Fu,Yucong Peng,Chaoran Xu,Kaibo Yu,Fuyi Liu,Shenglong Cao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C1q antibody [JL-1]

Dot Blot - Anti-C1q antibody [JL-1] (AB71940)

ELISA - Anti-C1q antibody [JL-1] (AB71940)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Epitope

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (49)

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