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AB68528

Anti-C1QL1 antibody

1

(1 Review)

|

(3 Publications)

Mouse Polyclonal C1QL1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human C1QL1.

View Alternative Names

C1QRF, CRF, CTRP14, C1QL1, C1q-related factor, C1q and tumor necrosis factor-related protein 14, Complement component 1 Q subcomponent-like 1, C1q/TNF-related protein 14

1 Images
Western blot - Anti-C1QL1 antibody (AB68528)
  • WB

Unknown

Western blot - Anti-C1QL1 antibody (AB68528)

All lanes:

Western blot - Anti-C1QL1 antibody (ab68528) at 1/500 dilution

Lane 1:

transfected 293T cell lysate at 25 µg

Lane 2:

non transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 26 kDa

Observed band size: 26 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human C1QL1.

O75973

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: 91% Water, 8% Sodium chloride, 0.6% Disodium hydrogenorthophosphate, 0.2% Potassium chloride, 0.2% Potassium phosphate monobasic
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C1QL1 also known as complement C1q-like protein 1 is a member of the C1q protein family. It has an approximate mass of 26 kDa. This protein is primarily expressed in the brain most notably in the cerebellum indicating its role in central nervous system processes. Researchers often investigate C1QL1 because of its structural similarities to complement components despite its distinct function within the neurological context.
Biological function summary

C1QL1 participates in synapse regulation and the maintenance of synaptic plasticity. It forms a part of a larger complex involving several other C1q-like proteins. These complexes contribute to the modulation of synapse formation and pruning by interacting with receptors on post-synaptic neurons. C1QL1's ability to influence synaptic connectivity makes it an important factor in cognitive development and neuroplasticity aspects fundamental to neuronal network adaptations.

Pathways

C1QL1 engages in pathways related to neural development and synaptic signaling. One significant pathway includes the complement cascade where its role diverges from traditional immune functions to support neural development. C1QL1 associates with proteins such as BAFF and APRIL through this pathway. It also plays a part in modulating the Wnt signaling pathway contributing to neuronal positioning and circuitry refinement.

C1QL1 has links to neurological conditions such as autism spectrum disorders and schizophrenia. Its role in synapse formation and plasticity makes it a significant factor in these disorders both characterized by altered synaptic connectivity. Connections to proteins such as NLGN1 and SHANK3 show how alterations in C1QL1 expression or function may lead to disruptions in synaptic balance highlighting its importance in maintaining normal cognitive function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
See full target information C1QL1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 41:e109187 PubMed35191554

2022

USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Aili Zhang,Zhi Huang,Weiwei Tao,Kui Zhai,Qiulian Wu,Jeremy N Rich,Wenchao Zhou,Shideng Bao

Journal of chemotherapy (Florence, Italy) 33:476-485 PubMed33825671

2021

C1q-like 1 is frequently up-regulated in lung adenocarcinoma and contributes to the proliferation and invasion of tumor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Jun Gao,Feng Chen,Lian-Jun Zhang

Cells 9: PubMed32635226

2020

Identification of Novel Molecular Markers of Human Th17 Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Sałkowska,Kaja Karaś,Iwona Karwaciak,Aurelia Walczak-Drzewiecka,Mariusz Krawczyk,Marta Sobalska-Kwapis,Jarosław Dastych,Marcin Ratajewski
View all publications
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Product promise

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