AB230660

Anti-C1QL3/CTRP13 antibody

Name: Anti-C1QL3/CTRP13 antibody (ab230660) | Abcam
Brand: Abcam Limited
SKU: AB230660

Be the first to review this product! Submit a review

(4 Publications)

Rabbit Polyclonal C1QL3/CTRP13 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human C1QL3 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CTRP13, C1QL3, Complement C1q-like protein 3, C1q and tumor necrosis factor-related protein 13, C1q/TNF-related protein 13

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1QL3/CTRP13 antibody (AB230660)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1QL3/CTRP13 antibody (AB230660)

Formalin-fixed, paraffin-embedded human brain cortex tissue stained for C1QL3/CTRP13 with ab230660 at a 1 : 100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-C1QL3/CTRP13 antibody (AB230660)

All lanes:

Western blot - Anti-C1QL3/CTRP13 antibody (ab230660) at 1/500 dilution

Lane 1:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Lane 2:

RAW 264.7 (Mouse macrophage cell line transformed with Abelson murine leukemia virus) whole cell lysate

Predicted band size: 26 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human C1QL3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q5VWW1

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.01% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C1QL3 also known as CTRP13 is a secreted protein belonging to the C1q/TNF-related protein family. The protein mass is approximately 28 kDa. It mainly expresses in the brain and adipose tissue but has been detected in other tissues too. C1QL3 has a significant role in synaptic function and development through interaction with receptors and neural membranes. Its structural resemblance to other C1q family members hints at potential similar mechanisms of action.

Biological function summary

C1QL3 plays a role in neural signaling and plasticity. It is implicated in the regulation of synapse formation and maintenance. Although it is not part of a larger complex its activity influences the assembly and disassembly of synaptic structures. Such interactions contribute to neural network adjustments essential for brain function. The role of C1QL3 in adipose tissue while less understood suggests a possible link to lipid metabolism.

Pathways

C1QL3 integrates into neural cellular communication pathways. It is linked to the synaptogenesis pathway where it influences synapse maturation. C1QL3 interacts with other proteins including BAIs which are G-protein-coupled receptors critical for transducing signals that guide synaptic connections. The involvement in these pathways underlines the importance of C1QL3 in maintaining neural circuitry balance and efficiency.

C1QL3 associates with neurological conditions such as schizophrenia and obesity. Its interaction with other synaptic proteins points to a possible role in disrupted synapse functioning which is often observed in schizophrenia. In obesity C1QL3 expression in adipose tissue can affect metabolic processes potentially linking it to other mediators like adiponectin that play roles in metabolism regulation. Understanding these associations can offer insights into disease mechanisms and potential therapeutic targets.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production (By similarity).

See full target information C1QL3

style

left-column

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 51: PubMed37052249

2023

Role of the voltage‑gated sodium channel Nav1.6 in glioma and candidate drugs screening.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Ai,Xudong Zhang,Xudong Hu,Jinte Gao,Jiyuan Liu,Shaowu Ou,Jun Wang

Cell transplantation 30:9636897211033275 PubMed34338573

2021

CTRP13 Protects H9c2 Cells Against Hypoxia/Reoxygenation (H/R)-Induced Injury Via Regulating the AMPK/Nrf2/ARE Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Weifeng Jiang,Jungang Song,Suitao Zhang,Yanyan Ye,Jun Wang,Yilin Zhang

Current medical science 40:48-54 PubMed32166664

2020

CTRP1 Attenuates UUO-induced Renal Fibrosis via AMPK/NOX4 Pathway in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Wen Li,Fan Cheng,Yi-Yan Songyang,Song-Yi-Sha Yang,Jie Wei,Yuan Ruan

Brain research bulletin 153:214-222 PubMed31499089

2019

miR-124 regulates cerebromicrovascular function in APP/PS1 transgenic mice via C1ql3.

Applications

Unspecified application

Species

Unspecified reactive species

Ang-Di Li,Lei Tong,Nan Xu,Yao Ye,Peng-Yin Nie,Zhen-Yu Wang,Li-Li Ji

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C1QL3/CTRP13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1QL3/CTRP13 antibody (AB230660)

Western blot - Anti-C1QL3/CTRP13 antibody (AB230660)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise